FIP1L1 Antibody - C-terminal region (ARP41031_P050)

• Product Number: ARP41031_P050
• Name: FIP1L1 Antibody - C-terminal region (ARP41031_P050)
• Protein Size (# AA): 594 amino acids
• Molecular Weight: 65kDa
• NCBI Gene Id: 81608
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: FIP1 like 1 (S. cerevisiae)
• Alias Symbols: Rhe, FIP1, hFip1
• Peptide Sequence: Synthetic peptide located within the following region: EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGD
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Zhao,X., (2005) J. Virol. 79 (7), 4270-4288
• Description of Target: FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. It binds to U-rich RNA sequence elements surrounding the poly(A) site. FIP1L1 may act to tether poly(A) polymerase to the CPSF complex.
• Protein Interactions: ZMYND19; CPSF4; NAA10; SGTA; GOLGA2; STAU1; UBC; WWOX; SUZ12; RNF2; EZH2; PRMT6; PRMT2; CLK2; HDAC9; CSNK2A1; LIG4; WDR33; CPSF2; CPSF3; CPSF1; NUP153; APP; COPS5; HNRNPA1; SRRM2; RNPS1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Blocking Peptide: For anti-FIP1L1 (ARP41031_P050) antibody is Catalog # AAP41031 (Previous Catalog # AAPS02208)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FIP1L1
• Uniprot ID: Q6UN15
• Protein Name: Pre-mRNA 3'-end-processing factor FIP1
• Sample Type Confirmation:

  FIP1L1 is supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_112179
• Purification: Affinity Purified
• Nucleotide Accession #: NM_030917
• Tested Species Reactivity: Human
• Gene Symbol: FIP1L1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%
• Image 1: Human Jurkat
  
  WB Suggested Anti-FIP1L1 Antibody Titration: 0.2-1 ug/ml
  Positive Control: Jurkat cell lysateFIP1L1 is supported by BioGPS gene expression data to be expressed in Jurkat
• Image 2: Human Brain
  
  Rabbit Anti-FIP1L1 antibody
  Catalog Number: ARP41031_P050
  Paraffin Embedded Tissue: Human Brain cell
  Cellular Data: Epithelial cells of renal tubule
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X