SFPQ Antibody - middle region (ARP40571_T100)

Data Sheet
 
Product Number ARP40571_T100
Product Page www.avivasysbio.com/sfpq-antibody-middle-region-arp40571-t100.html
Name SFPQ Antibody - middle region (ARP40571_T100)
Protein Size (# AA) 707 amino acids
Molecular Weight 78kDa
NCBI Gene Id 6421
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Splicing factor proline/glutamine-rich
Alias Symbols PSF, POMP100, PPP1R140
Peptide Sequence Synthetic peptide located within the following region: PVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Rosonina,E., (2005) Mol. Cell. Biol. 25 (15), 6734-6746
Description of Target SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.
Protein Interactions SNRPA; PTBP1; NONO; HDAC2; FUS; HUWE1; UBC; SUMO2; MDM2; STAU1; RPA3; RPA2; RPA1; ERG; ASB18; ASB12; WWOX; ASB3; EED; rev; TIMM23B; APBB1; PIN1; WBP4; TCERG1; GAS7; PRPF40A; PARK2; UBD; CD81; PAN2; RNF43; WHSC1; VCAM1; SMAD5; ITGA4; FN1; CSNK2A1; BTK; DNA
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-SFPQ (ARP40571_T100) antibody
Blocking Peptide For anti-SFPQ (ARP40571_T100) antibody is Catalog # AAP40571 (Previous Catalog # AAPP22749)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SFPQ
Uniprot ID P23246
Protein Name Splicing factor, proline- and glutamine-rich
Sample Type Confirmation

SFPQ is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_005057
Purification Protein A purified
Nucleotide Accession # NM_005066
Tested Species Reactivity Human
Gene Symbol SFPQ
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Image 1
Human Muscle
Rabbit Anti-SFPQ Antibody
Catalog Number: ARP40571
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Image 2
Human Jurkat
WB Suggested Anti-SFPQ Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysateSFPQ is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Image 3
Human Heart
Rabbit Anti-SFPQ antibody
Catalog Number: ARP40571
Paraffin Embedded Tissue: Human Heart
cell Cellular Data: cardiac cell
Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X
 

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