Product Number |
ARP40571_T100 |
Product Page |
www.avivasysbio.com/sfpq-antibody-middle-region-arp40571-t100.html |
Name |
SFPQ Antibody - middle region (ARP40571_T100) |
Protein Size (# AA) |
707 amino acids |
Molecular Weight |
78kDa |
NCBI Gene Id |
6421 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Splicing factor proline/glutamine-rich |
Alias Symbols |
PSF, POMP100, PPP1R140 |
Peptide Sequence |
Synthetic peptide located within the following region: PVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Rosonina,E., (2005) Mol. Cell. Biol. 25 (15), 6734-6746 |
Description of Target |
SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. |
Protein Interactions |
SNRPA; PTBP1; NONO; HDAC2; FUS; HUWE1; UBC; SUMO2; MDM2; STAU1; RPA3; RPA2; RPA1; ERG; ASB18; ASB12; WWOX; ASB3; EED; rev; TIMM23B; APBB1; PIN1; WBP4; TCERG1; GAS7; PRPF40A; PARK2; UBD; CD81; PAN2; RNF43; WHSC1; VCAM1; SMAD5; ITGA4; FN1; CSNK2A1; BTK; DNA |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SFPQ (ARP40571_T100) antibody |
Blocking Peptide |
For anti-SFPQ (ARP40571_T100) antibody is Catalog # AAP40571 (Previous Catalog # AAPP22749) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human SFPQ |
Uniprot ID |
P23246 |
Protein Name |
Splicing factor, proline- and glutamine-rich |
Sample Type Confirmation |
SFPQ is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_005057 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_005066 |
Tested Species Reactivity |
Human |
Gene Symbol |
SFPQ |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
Image 1 | Human Muscle
| Rabbit Anti-SFPQ Antibody Catalog Number: ARP40571 Paraffin Embedded Tissue: Human Muscle Cellular Data: Skeletal muscle cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
|
Image 2 | Human Jurkat
| WB Suggested Anti-SFPQ Antibody Titration: 5.0ug/ml Positive Control: Jurkat cell lysateSFPQ is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
|
Image 3 | Human Heart
| Rabbit Anti-SFPQ antibody
Catalog Number: ARP40571
Paraffin Embedded Tissue: Human Heart
cell Cellular Data: cardiac cell
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
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