| Product Number |
ARP40508_T100 |
| Product Page |
www.avivasysbio.com/eif2s1-antibody-c-terminal-region-arp40508-t100.html |
| Name |
EIF2S1 Antibody - C-terminal region (ARP40508_T100) |
| Protein Size (# AA) |
315 amino acids |
| Molecular Weight |
35kDa |
| Subunit |
1 |
| NCBI Gene Id |
1965 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
| Alias Symbols |
EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha |
| Peptide Sequence |
Synthetic peptide located within the following region: RGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Marciniak,S.J., (2006) J. Cell Biol. 172 (2), 201-209 |
| Description of Target |
The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha.The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987).[supplied by OMIM]. |
| Protein Interactions |
HUWE1; UBC; SUMO2; SUMO3; RPA3; RPA2; RPA1; RNF2; EIF2S3; DARS; RPS27L; EEF1E1; AIMP1; EIF2S2; RPLP0; RPL27A; RPL15; RPL13; RPL7A; QARS; MARS; MAP4; TERT; NPM1; MMS19; Dlg4; VCAM1; UPF1; ITGA4; FN1; CSNK2A1; EIF2AK2; NCOA5; POP1; STRN; YBX1; DDX1; TMED9; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-EIF2S1 (ARP40508_T100) antibody |
| Blocking Peptide |
For anti-EIF2S1 (ARP40508_T100) antibody is Catalog # AAP40508 (Previous Catalog # AAPP22711) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human EIF2S1 |
| Uniprot ID |
P05198 |
| Protein Name |
Eukaryotic translation initiation factor 2 subunit 1 |
| Protein Accession # |
NP_004085 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_004094 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
EIF2S1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100% |
| Image 1 | Human Lung
 | Rabbit Anti-EIF2S1 Antibody
Catalog Number: ARP40508
Paraffin Embedded Tissue: Human Lung
Cellular Data: Alveolar cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 2 | human Kidney
 | Rabbit Anti-EIF2S1 Antibody
Catalog Number: ARP40508
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 3 | Human HepG2
 | WB Suggested Anti-EIF2S1 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate |
|
