PABPC4 Antibody - N-terminal region (ARP40496_T100)

Data Sheet
 
Product Number ARP40496_T100
Product Page www.avivasysbio.com/pabpc4-antibody-n-terminal-region-arp40496-t100.html
Name PABPC4 Antibody - N-terminal region (ARP40496_T100)
Protein Size (# AA) 644 amino acids
Molecular Weight 71kDa
NCBI Gene Id 8761
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Poly(A) binding protein, cytoplasmic 4 (inducible form)
Alias Symbols APP1, APP-1, PABP4, iPABP
Peptide Sequence Synthetic peptide located within the following region: AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKS
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Lehner,B. (2004) Genome Res. 14 (7), 1315-1323
Description of Target Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
Protein Interactions FBXW11; UBC; IVNS1ABP; STAU1; RPA3; RPA2; RPA1; WWOX; SUZ12; RNF2; EZH2; BMI1; NCAPD2; DDX5; TARDBP; SRPK2; CLK3; YWHAQ; UBD; EIF2AK2; PAN2; UBL4A; SMAD9; ITGA4; IL7R; IFIT3; IFIT1; IFIT2; FN1; IGBP1; NUBP2; CAND1; DCUN1D1; COPS5; CUL1; CUL2; CUL3; CUL4A;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-PABPC4 (ARP40496_T100) antibody
Blocking Peptide For anti-PABPC4 (ARP40496_T100) antibody is Catalog # AAP40496 (Previous Catalog # AAPP22264)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PABPC4
Uniprot ID Q13310
Protein Name Polyadenylate-binding protein 4
Protein Accession # NP_003810
Purification Protein A purified
Nucleotide Accession # NM_003819
Tested Species Reactivity Human
Gene Symbol PABPC4
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%
Image 1
Human HepG2
WB Suggested Anti-PABPC4 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
Image 2
Human Kidney
Rabbit Anti-PABPC4 Antibody
Catalog Number: ARP40496
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
 

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