Product Number |
ARP40496_T100 |
Product Page |
www.avivasysbio.com/pabpc4-antibody-n-terminal-region-arp40496-t100.html |
Name |
PABPC4 Antibody - N-terminal region (ARP40496_T100) |
Protein Size (# AA) |
644 amino acids |
Molecular Weight |
71kDa |
NCBI Gene Id |
8761 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Poly(A) binding protein, cytoplasmic 4 (inducible form) |
Alias Symbols |
APP1, APP-1, PABP4, iPABP |
Peptide Sequence |
Synthetic peptide located within the following region: AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Lehner,B. (2004) Genome Res. 14 (7), 1315-1323 |
Description of Target |
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. |
Protein Interactions |
FBXW11; UBC; IVNS1ABP; STAU1; RPA3; RPA2; RPA1; WWOX; SUZ12; RNF2; EZH2; BMI1; NCAPD2; DDX5; TARDBP; SRPK2; CLK3; YWHAQ; UBD; EIF2AK2; PAN2; UBL4A; SMAD9; ITGA4; IL7R; IFIT3; IFIT1; IFIT2; FN1; IGBP1; NUBP2; CAND1; DCUN1D1; COPS5; CUL1; CUL2; CUL3; CUL4A; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PABPC4 (ARP40496_T100) antibody |
Blocking Peptide |
For anti-PABPC4 (ARP40496_T100) antibody is Catalog # AAP40496 (Previous Catalog # AAPP22264) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human PABPC4 |
Uniprot ID |
Q13310 |
Protein Name |
Polyadenylate-binding protein 4 |
Protein Accession # |
NP_003810 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_003819 |
Tested Species Reactivity |
Human |
Gene Symbol |
PABPC4 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%; Zebrafish: 79% |
Image 1 | Human HepG2
| WB Suggested Anti-PABPC4 Antibody Titration: 1.25ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate |
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Image 2 | Human Kidney
| Rabbit Anti-PABPC4 Antibody Catalog Number: ARP40496 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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