SNRP70 Antibody - C-terminal region (ARP40439_P050)

• Product Number: ARP40439_P050
• Name: SNRP70 Antibody - C-terminal region (ARP40439_P050)
• Protein Size (# AA): 437 amino acids
• Molecular Weight: 52 kDa
• NCBI Gene Id: 6625
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Small nuclear ribonucleoprotein 70kDa (U1)
• Description:
  View product citations for SNRP70 Antibodies on CiteAb
• Alias Symbols: RPU1, Snp1, U1AP, U170K, U1RNP, RNPU1Z, SNRP70, U1-70K
• Peptide Sequence: Synthetic peptide located within the following region: RERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDR
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Brandenberger,R., (2004) Nat. Biotechnol. 22 (6), 707-716
• Description of Target: SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
• Protein Interactions: IL32; UBC; NEDD8; LIN28A; EZH2; SUZ12; EED; RNF2; rev; WBP4; SRPK2; SRPK1; MYC; SRPK3; HDAC2; PAN2; SMURF2; PRPF40A; CDKL3; RNF11; PRKD2; SKIL; RELA; RASGRF1; SMAD9; SMAD5; SMAD4; SMAD3; SMAD2; CHERP; PRMT5; UBL4A; VCAM1; SMAD1; ITGA4; IL7R; IFIT3; IFIT1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation: Relative Expression (Western Blot)
  
• Blocking Peptide: For anti-SNRNP70 (ARP40439_P050) antibody is Catalog # AAP40439 (Previous Catalog # AAPP22180)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SNRP70
• Uniprot ID: P08621
• Protein Name: U1 small nuclear ribonucleoprotein 70 kDa
• Publications:

  Franklin, S. et al. Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol. Cell. Proteomics 11, M111.014258 (2012). 22270000

  Franklin, S. et al. Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol. Cell. Proteomics 10, M110.000703 (2011). 20807835

  Serini, S. et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and beta-catenin nuclear translocation. Carcinogenesis 33, 164-73 (2012). 22045024

• Sample Type Confirmation:

  SNRNP70 is supported by BioGPS gene expression data to be expressed in HepG2

• Protein Accession #: NP_003080
• Purification: Affinity Purified
• Nucleotide Accession #: NM_003089
• Tested Species Reactivity: Human
• Gene Symbol: SNRNP70
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
• Image 1: Human Hela
  
  Host: Rabbit
  Target Name: SNRP70
  Sample Tissue: Human Hela
  Antibody Dilution: 1.0ug/ml
• Image 2: Human Pineal Tissue
  
  Rabbit Anti-SNRNP70 Antibody
  Catalog Number: ARP40439_P050
  Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue
  Observed Staining: Nuclear in pinealocytes
  Primary Antibody Concentration: 1:100
  Secondary Antibody: Donkey anti-Rabbit-Cy3
  Secondary Antibody Concentration: 1:200
  Magnification: 20X
  Exposure Time: 0.5 - 2.0 sec
  
• Image 3: Human DLD1 Whole Cell
  
  Host: Rabbit
  Target Name: SNRNP70
  Sample Tissue: Human DLD1 Whole Cell
  Antibody Dilution: 1ug/ml