PTBP1 Antibody - N-terminal region (ARP40421_P050)

• Product Number: ARP40421_P050
• Name: PTBP1 Antibody - N-terminal region (ARP40421_P050)
• Protein Size (# AA): 531 amino acids
• Molecular Weight: 58kDa
• NCBI Gene Id: 5725
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Polypyrimidine tract binding protein 1
• Alias Symbols: PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I
• Peptide Sequence: Synthetic peptide located within the following region: RGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHI
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Robinson,F. (2006) J. Biol. Chem. 281 (2), 800-806
• Description of Target: PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
• Protein Interactions: UBC; SNRPA; SFPQ; PTBP1; NONO; LGR4; MDM2; RPA3; RPA2; RPA1; BMI1; SUZ12; EED; RNF2; DIMT1; YBX3; AIMP2; SPTAN1; RPS27; QARS; YBX1; RPSA; ILF2; HNRNPU; HNRNPD; HNRNPA2B1; FAU; EPRS; EIF4G1; APBB1; ABCF1; NELFB; G3BP1; AIMP1; EIF2B2; IQGAP1; TARDBP; SRPK2;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-PTBP1 (ARP40421_P050) antibody is Catalog # AAP40421 (Previous Catalog # AAPS03003)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTBP1
• Uniprot ID: P26599
• Protein Name: Polypyrimidine tract-binding protein 1
• Sample Type Confirmation:

  PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Daudi

• Protein Accession #: NP_114368
• Purification: Affinity Purified
• Nucleotide Accession #: NM_031991
• Tested Species Reactivity: Human
• Gene Symbol: PTBP1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 91%; Rat: 100%; Zebrafish: 93%
• Image 1: Human HepG2
  
  Host: Rabbit
  Target Name: PTBP1
  Sample Tissue: Human HepG2
  Antibody Dilution: 1.0ug/ml