| Product Number |
ARP40418_T100 |
| Product Page |
www.avivasysbio.com/psma1-antibody-n-terminal-region-arp40418-t100.html |
| Name |
PSMA1 Antibody - N-terminal region (ARP40418_T100) |
| Protein Size (# AA) |
263 amino acids |
| Molecular Weight |
29kDa |
| Subunit |
alpha type-1 |
| NCBI Gene Id |
5682 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Proteasome (prosome, macropain) subunit, alpha type, 1 |
| Alias Symbols |
NU, HC2, PROS30, HEL-S-275 |
| Peptide Sequence |
Synthetic peptide located within the following region: MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Conticello,S.G., (2003) Curr. Biol. 13 (22), 2009-2013 |
| Description of Target |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA1 is a member of the peptidase T1A family which is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. |
| Protein Interactions |
PRDM14; CEP70; CCDC102B; GNPTAB; CEP72; KCTD9; ROPN1; ABI3; SH3GLB1; APIP; LDOC1; MTUS2; MAPRE3; MAPRE1; IKZF3; MID2; EHMT2; PNMA2; IKZF1; TRIM10; HUWE1; HOMER3; PNMA1; KRT38; BLZF1; MAD1L1; MKRN3; REL; PSMA3; MLH1; KRT31; KRT15; KRTAP5-9; GOLGA2; CDA; CC |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PSMA1 (ARP40418_T100) antibody |
| Blocking Peptide |
For anti-PSMA1 (ARP40418_T100) antibody is Catalog # AAP40418 (Previous Catalog # AAPS03001) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human PSMA1 |
| Uniprot ID |
P25786 |
| Protein Name |
Proteasome subunit alpha type-1 |
| Protein Accession # |
NP_002777 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_002786 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PSMA1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 86% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-PSMA1 Antibody Titration: 1.25ug/ml
Positive Control: Jurkat cell lysate |
|
