Product Number |
ARP40412_T100 |
Product Page |
www.avivasysbio.com/ppp1r8-antibody-middle-region-arp40412-t100.html |
Name |
PPP1R8 Antibody - middle region (ARP40412_T100) |
Protein Size (# AA) |
127 amino acids |
Molecular Weight |
14kDa |
NCBI Gene Id |
5511 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Protein phosphatase 1, regulatory subunit 8 |
Alias Symbols |
ARD1, ARD-1, NIPP1, NIPP-1, PRO2047 |
Peptide Sequence |
Synthetic peptide located within the following region: PNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Lesage,B., (2004) J. Biol. Chem. 279 (53), 55978-55984 |
Description of Target |
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. |
Protein Interactions |
APPBP2; UBC; FBXO25; HMGA1; WDR77; CTNNBL1; PPIL1; PPP1CC; PPP1CA; NF2; APP; SF3A2; Cep72; PPP1CB; SUZ12; RBBP4; EZH2; EED; RBM48; SF3B1; SETDB1; MELK; HDAC2; C14orf1; STC2; CDC5L; CRMP1; PRKACA; GBP2; LYN; CSNK2A2; CSNK2A1; NME2; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PPP1R8 (ARP40412_T100) antibody |
Specificity |
This antibody recognizes isoform-gamma |
Blocking Peptide |
For anti-PPP1R8 (ARP40412_T100) antibody is Catalog # AAP40412 (Previous Catalog # AAPP22153) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PPP1R8 |
Uniprot ID |
Q12972 |
Protein Name |
Nuclear inhibitor of protein phosphatase 1 |
Protein Accession # |
NP_002704 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_002713 |
Tested Species Reactivity |
Human |
Gene Symbol |
PPP1R8 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91% |
Image 1 | Human Thymus
| WB Suggested Anti-PPP1R8 Antibody Titration: 2.5ug/ml ELISA Titer: 1:312500 Positive Control: Human Thymus |
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Image 2 | Human Kidney
| Rabbit Anti-PPP1R8 Antibody Catalog Number: ARP40412 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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