HNRPK Antibody - C-terminal region (ARP40387_T100)

• Product Number: ARP40387_T100
• Name: HNRPK Antibody - C-terminal region (ARP40387_T100)
• Protein Size (# AA): 463 amino acids
• Molecular Weight: 51kDa
• NCBI Gene Id: 3190
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Heterogeneous nuclear ribonucleoprotein K
• Alias Symbols: AUKS, CSBP, TUNP, HNRPK
• Peptide Sequence: Synthetic peptide located within the following region: YSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGAS
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Aris,J.P. (2006) Br. J. Cancer 94 (4), 586-592
• Description of Target: HNRPK belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.
• Protein Interactions: ZNF385C; ZFC3H1; RBMY1F; ZNF792; HNRNPLL; YTHDC1; PRR3; CCDC33; FBXL18; MARK4; PCDHB14; DALRD3; RASD1; RBMX; PRPF31; SORBS3; ABI2; HUWE1; MATR3; QKI; UBC; U2AF1; TYK2; TP53; SPG7; ZNRF2P1; C6orf226; RTP5; AQP5; GRB2; FUS; DOCK2; CIRBP; SNRPA; RBMY1A1; RBM
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-HNRNPK (ARP40387_T100) antibody is Catalog # AAP40387 (Previous Catalog # AAPP22131)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPK
• Uniprot ID: P61978
• Protein Name: Heterogeneous nuclear ribonucleoprotein K
• Protein Accession #: NP_112552
• Purification: Protein A purified
• Nucleotide Accession #: NM_031262
• Tested Species Reactivity: Human
• Gene Symbol: HNRNPK
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Image 1: Human skeletal muscle
  
  Rabbit Anti-HNRPK Antibody
  Catalog Number: ARP40387
  Paraffin Embedded Tissue: Human Skeletal Muscle
  Cellular Data: Skeletal muscle
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X
• Image 2: Human HepG2
  
  WB Suggested Anti-HNRPK Antibody Titration: 1.25ug/ml
  ELISA Titer: 1:1562500
  Positive Control: HepG2 cell lysate