| Product Number |
ARP40297_P050 |
| Product Page |
www.avivasysbio.com/cars-antibody-n-terminal-region-arp40297-p050.html |
| Name |
CARS Antibody - N-terminal region (ARP40297_P050) |
| Protein Size (# AA) |
738 amino acids |
| Molecular Weight |
81kDa |
| NCBI Gene Id |
833 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Cysteinyl-tRNA synthetase |
| Alias Symbols |
CARS, MDBH, CYSRS, MCDDBH, MGC:11246 |
| Peptide Sequence |
Synthetic peptide located within the following region: MQTPPLQQPHQEQVFLAFLVIVIPSFLTKEVFIPQDGKKVTWYCCGPTVY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kimura,K., (2006) Genome Res. 16 (1), 55-65 |
| Description of Target |
CARS is a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| Protein Interactions |
UBC; DNM1L; CAND1; LUC7L2; THUMPD3; JMJD6; XPO7; FAF1; SEC23A; SEC24D; HIRIP3; HIST1H4A; TTC1; TROVE2; SHMT1; PPM1G; PPAT; PAWR; KARS; IDE; HSPA4; GFPT1; GART; GARS; APEH; APP; SUMO2; PACSIN1; PACSIN3; PACSIN2; PSTPIP1; EEF1G; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CARS (ARP40297_P050) antibody |
| Blocking Peptide |
For anti-CARS (ARP40297_P050) antibody is Catalog # AAP40297 (Previous Catalog # AAPP22804) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CARS |
| Uniprot ID |
P49589 |
| Protein Accession # |
NP_001014438 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001014438 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CARS |
| Predicted Species Reactivity |
Human, Rat |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100%; Rat: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-CARS Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate |
| | Image 2 | Human Lung
 | Rabbit Anti-CARS Antibody
Catalog Number: ARP40297
Paraffin Embedded Tissue: Human Lung
Cellular Data: Alveolar cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
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