HNRPD Antibody - N-terminal region (ARP40239_T100)

• Product Number: ARP40239_T100
• Name: HNRPD Antibody - N-terminal region (ARP40239_T100)
• Protein Size (# AA): 355 amino acids
• Molecular Weight: 38 kDa
• NCBI Gene Id: 3184
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
• Alias Symbols: P37, AUF1, AUF1A, HNRPD, hnRNPD0
• Peptide Sequence: Synthetic peptide located within the following region: AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTK
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Dhakras,P.S., Am. J. Physiol. Renal Physiol. 290 (2), F313-F318 (2006)
• Description of Target: HNRPD belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
• Protein Interactions: NCL; FUS; KAT2B; SUMO2; SUMO3; IVNS1ABP; STAU1; UBC; NEDD8; MDM2; ERG; RPA3; RPA2; RPA1; ASB2; EED; rev; ERI1; RPS12; PTBP1; PAFAH1B3; WNK1; IPO11; EIF3K; KHSRP; DENR; PARK2; DGCR2; GTF3C3; PDLIM7; UQCRC1; HIRA; SNAPC4; SLC3A2; SDF2; COG7; TMEM261; ABCC10
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Blocking Peptide: For anti-HNRNPD (ARP40239_T100) antibody is Catalog # AAP40239 (Previous Catalog # AAPP22083)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPD
• Uniprot ID: Q14103
• Protein Name: Heterogeneous nuclear ribonucleoprotein D0
• Sample Type Confirmation:

  HNRNPD is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_112738
• Purification: Protein A purified
• Nucleotide Accession #: NM_031370
• Tested Species Reactivity: Human
• Gene Symbol: HNRNPD
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 77%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
• Image 1: Human Heart
  
  Rabbit Anti-HNRNPD Antibody
  Catalog Number: ARP40239
  Paraffin Embedded Tissue: Human cardiac cell
  Cellular Data: Epithelial cells of renal tubule
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X
• Image 2: Human Jurkat
  
  WB Suggested Anti-HNRPD Antibody Titration: 1.25ug/ml
  ELISA Titer: 1:62500
  Positive Control: Jurkat cell lysateHNRNPD is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
• Image 3: Human Adult Placenta
  
  Host: Rabbit
  Target Name: CHAD
  Sample Type: Human Adult Placenta
  Antibody Dilution: 1.0ug/ml
• Image 4: Human Intestine
  
  Rabbit Anti-HNRPD Antibody
  Catalog Number: ARP40239
  Paraffin Embedded Tissue: Human Intestine
  Cellular Data: Epithelial cells of intestinal villas
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X