APTX Antibody - C-terminal region (ARP40014_T100)

Data Sheet
 
Product Number ARP40014_T100
Product Page www.avivasysbio.com/aptx-antibody-c-terminal-region-arp40014-t100.html
Name APTX Antibody - C-terminal region (ARP40014_T100)
Protein Size (# AA) 342 amino acids
Molecular Weight 38kDa
NCBI Gene Id 54840
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Aprataxin
Alias Symbols AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT
Peptide Sequence Synthetic peptide located within the following region: VIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWTQ
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Ahnesorg,P., (2006) Cell 124 (2), 301-313
Description of Target APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Protein Interactions PNMA1; UBC; SUMO1; NEDD8; LIG3; HSPA4; XRCC1; DDX21; CNTROB; TSPYL2; CALCOCO1; SYT17; ZNF639; MAPKBP1; CEP350; PICK1; XRCC4; TRIM37; MBP; HIVEP1; BANF1; PARP1; TP53;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-APTX (ARP40014_T100) antibody
Blocking Peptide For anti-APTX (ARP40014_T100) antibody is Catalog # AAP40014 (Previous Catalog # AAPP21922)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human APTX
Uniprot ID Q6JV85
Protein Name Aprataxin
Publications

Dopeso, H. et al. Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment. Clin. Cancer Res. 16, 2375-82 (2010). 20371676

Protein Accession # NP_778243
Purification Protein A purified
Nucleotide Accession # NM_175073
Tested Species Reactivity Human
Gene Symbol APTX
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 92%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Image 1
Human NCI-H226
WB Suggested Anti-APTX Antibody Titration: 2.5ug/ml
ELISA Titer: 1:1562500
Positive Control: NCI-H226 cell lysate
Image 2
Human kidney
Human kidney
 

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