DEAF1 Antibody - N-terminal region (ARP39467_P050)

Data Sheet
 
Product Number ARP39467_P050
Product Page www.avivasysbio.com/deaf1-antibody-n-terminal-region-arp39467-p050.html
Name DEAF1 Antibody - N-terminal region (ARP39467_P050)
Protein Size (# AA) 565 amino acids
Molecular Weight 59kDa
NCBI Gene Id 10522
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Deformed epidermal autoregulatory factor 1 (Drosophila)
Alias Symbols SPN, NUDR, VSVS, MRD24, ZMYND5, NEDHELS
Peptide Sequence Synthetic peptide located within the following region: EEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPD
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Czesak,M., (2006) J. Neurosci. 26 (6), 1864-1871
Description of Target DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Protein Interactions IRF7; IRF3; CREB1; PELI1; PELI2; HRSP12; GSK3B; GSK3A; CDKN2A; PPP1CC; PPP1CA; CDC37; AIMP2; TK1; RAD23B; PIN1; HRAS; FHL1; CDKN1A; ASCC2; INTS1; LMO4; DEAF1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-DEAF1 (ARP39467_P050) antibody
Blocking Peptide For anti-DEAF1 (ARP39467_P050) antibody is Catalog # AAP39467 (Previous Catalog # AAPP21481)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human DEAF1
Uniprot ID O75398
Protein Name Deformed epidermal autoregulatory factor 1 homolog
Protein Accession # NP_066288
Purification Affinity Purified
Nucleotide Accession # NM_021008
Tested Species Reactivity Human
Gene Symbol DEAF1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Yeast
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 83%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 100%
Image 1
Hum. Fetal Lung
Hum. Fetal Lung
Image 2
Hum. Fetal Muscle
Hum. Fetal Muscle
Image 3
Hum. Adult Placenta
Hum. Adult Placenta
Image 4
Human Brain
WB Suggested Anti-DEAF1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human brain
 

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