Product Number |
ARP39381_T100 |
Product Page |
www.avivasysbio.com/dmap1-antibody-c-terminal-region-arp39381-t100.html |
Name |
DMAP1 Antibody - C-terminal region (ARP39381_T100) |
Protein Size (# AA) |
467 amino acids |
Molecular Weight |
53kDa |
NCBI Gene Id |
55929 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
DNA methyltransferase 1 associated protein 1 |
Alias Symbols |
EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1 |
Peptide Sequence |
Synthetic peptide located within the following region: PGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Oh,J.H., et al., (2005) Mamm. Genome 16 (12), 942-954 |
Description of Target |
DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. |
Protein Interactions |
SOX2; UBC; RNF2; HECW2; RUVBL2; SRCAP; CFDP1; RUVBL1; DENR; VPS72; TOMM34; TSG101; H2AFZ; DAXX; SMARCAD1; SUMO2; EPC1; ACTL6A; ACTA1; PPP2R2D; ING3; MORF4L1; BRD8; KAT5; TRRAP; YEATS4; EP400; EPC2; MYC; MAX; ACTG1; ACTB; MRGBP; MORF4L2; MNAT1; HDAC1; tat; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-DMAP1 (ARP39381_T100) antibody |
Blocking Peptide |
For anti-DMAP1 (ARP39381_T100) antibody is Catalog # AAP39381 (Previous Catalog # AAPP21392) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human DMAP1 |
Uniprot ID |
Q9NPF5 |
Protein Name |
DNA methyltransferase 1-associated protein 1 |
Protein Accession # |
NP_061973 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_019100 |
Tested Species Reactivity |
Human |
Gene Symbol |
DMAP1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | Human Jurkat
| WB Suggested Anti-DMAP1 Antibody Titration: 5.0ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate |
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