DMAP1 Antibody - C-terminal region (ARP39381_T100)

Data Sheet
 
Product Number ARP39381_T100
Product Page www.avivasysbio.com/dmap1-antibody-c-terminal-region-arp39381-t100.html
Name DMAP1 Antibody - C-terminal region (ARP39381_T100)
Protein Size (# AA) 467 amino acids
Molecular Weight 53kDa
NCBI Gene Id 55929
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name DNA methyltransferase 1 associated protein 1
Alias Symbols EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1
Peptide Sequence Synthetic peptide located within the following region: PGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Oh,J.H., et al., (2005) Mamm. Genome 16 (12), 942-954
Description of Target DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Protein Interactions SOX2; UBC; RNF2; HECW2; RUVBL2; SRCAP; CFDP1; RUVBL1; DENR; VPS72; TOMM34; TSG101; H2AFZ; DAXX; SMARCAD1; SUMO2; EPC1; ACTL6A; ACTA1; PPP2R2D; ING3; MORF4L1; BRD8; KAT5; TRRAP; YEATS4; EP400; EPC2; MYC; MAX; ACTG1; ACTB; MRGBP; MORF4L2; MNAT1; HDAC1; tat;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-DMAP1 (ARP39381_T100) antibody
Blocking Peptide For anti-DMAP1 (ARP39381_T100) antibody is Catalog # AAP39381 (Previous Catalog # AAPP21392)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human DMAP1
Uniprot ID Q9NPF5
Protein Name DNA methyltransferase 1-associated protein 1
Protein Accession # NP_061973
Purification Protein A purified
Nucleotide Accession # NM_019100
Tested Species Reactivity Human
Gene Symbol DMAP1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Image 1
Human Jurkat
WB Suggested Anti-DMAP1 Antibody Titration: 5.0ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
 

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

AVIVA SYSTEMS BIOLOGY
10211 Pacific Mesa Blvd, Ste 401, San Diego, CA 92121 USA | Tel: (858)552-6979 | info@avivasysbio.com