| Product Number |
ARP39276_T100 |
| Product Page |
www.avivasysbio.com/klhl3-antibody-n-terminal-region-arp39276-t100.html |
| Name |
KLHL3 Antibody - N-terminal region (ARP39276_T100) |
| Protein Size (# AA) |
587 amino acids |
| Molecular Weight |
65kDa |
| NCBI Gene Id |
26249 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Kelch-like 3 (Drosophila) |
| Alias Symbols |
PHA2D |
| Peptide Sequence |
Synthetic peptide located within the following region: MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLC |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lai,F., et al., (2000) Genomics 66 (1), 65-75 |
| Description of Target |
KLHL3 protein contains a poxvirus and zinc finger domain at the N-terminus and six tandem repeats (kelch repeats) at the C-terminus. At the amino acid level, KLHL3 shares 77% similarity with Drosophila kelch and 89% similarity with Mayven (KLHL2), another human kelch homolog. At least three isoforms are produced and may be the result of alternative promoter usage. The KLHL3 maps within the smallest commonly deleted segment in myeloid leukemias characterized by a deletion of 5q; however, no inactivating mutations of KLHL3 could be detected in malignant myeloid disorders with loss of 5q. |
| Protein Interactions |
WNK4; KLHL12; KLHL3; KEAP1; MORF4L2; CUL3; UBC; C6orf165; WNK3; WNK2; WNK1; RBX1; SLC12A3; ELAVL1; SYNCRIP; SYT2; OPRD1; GNAO1; GNAI1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-KLHL3 (ARP39276_T100) antibody |
| Blocking Peptide |
For anti-KLHL3 (ARP39276_T100) antibody is Catalog # AAP39276 (Previous Catalog # AAPY00886) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human KLHL3 |
| Uniprot ID |
Q9UH77 |
| Protein Name |
Kelch-like protein 3 |
| Protein Accession # |
NP_059111 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_017415 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
KLHL3 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Dog: 91%; Guinea Pig: 85%; Human: 100%; Rabbit: 100%; Rat: 93% |
| Image 1 | Human HepG2
 | WB Suggested Anti-KLHL3 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate |
|
| Image 2 | Human Ovary Tumor, Human Liver
 | Host: Rabbit
Target: KLHL3
Positive control (+): Human Ovary Tumor (T-OV)
Negative control (-): Human Liver (LI)
Antibody concentration: 0.5ug/ml |
|
