Product Number |
ARP39069_T100 |
Product Page |
www.avivasysbio.com/nr2e3-antibody-n-terminal-region-arp39069-t100.html |
Name |
NR2E3 Antibody - N-terminal region (ARP39069_T100) |
Protein Size (# AA) |
410 amino acids |
Molecular Weight |
45kDa |
NCBI Gene Id |
10002 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Nuclear receptor subfamily 2, group E, member 3 |
Description |
|
Alias Symbols |
PNR, RNR, rd7, ESCS, RP37 |
Peptide Sequence |
Synthetic peptide located within the following region: METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVC |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Hayashi,T., Ophthalmology 112 (12), 2115 (2005) |
Description of Target |
NR2E3 is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. NR2E3 is a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome.This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Protein Interactions |
BCL11A; SIN3A; DHX30; TBL3; MYBBP1A; NCOR1; HDAC3; RBL1; RBBP7; RBBP4; HDAC1; CDK9; VDR; DEDD2; RBFOX2; IRF9; ZNF232; SNAPC1; PPARG; HOXC13; NR3C1; ELAVL2; POLR3D; RARA; NR1D1; CRX; RXRB; RXRA; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-NR2E3 (ARP39069_T100) antibody |
Blocking Peptide |
For anti-NR2E3 (ARP39069_T100) antibody is Catalog # AAP39069 (Previous Catalog # AAPS04208) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human NR2E3 |
Uniprot ID |
Q9Y5X4 |
Protein Name |
Photoreceptor-specific nuclear receptor |
Publications |
Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 7, 10662 (2017). 28878246
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Mol Med. 4, 52-67 (2012). 22174013 |
Protein Accession # |
NP_055064 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_014249 |
Tested Species Reactivity |
Human |
Gene Symbol |
NR2E3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Pig |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Human: 100%; Mouse: 93%; Pig: 79%; Rat: 93% |
Image 1 | Human HepG2
| WB Suggested Anti-NR2E3 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysate |
|