NR2E3 Antibody - N-terminal region (ARP39069_T100)

Data Sheet
 
Product Number ARP39069_T100
Product Page www.avivasysbio.com/nr2e3-antibody-n-terminal-region-arp39069-t100.html
Name NR2E3 Antibody - N-terminal region (ARP39069_T100)
Protein Size (# AA) 410 amino acids
Molecular Weight 45kDa
NCBI Gene Id 10002
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Nuclear receptor subfamily 2, group E, member 3
Description
Alias Symbols PNR, RNR, rd7, ESCS, RP37
Peptide Sequence Synthetic peptide located within the following region: METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVC
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Hayashi,T., Ophthalmology 112 (12), 2115 (2005)
Description of Target NR2E3 is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. NR2E3 is a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome.This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein Interactions BCL11A; SIN3A; DHX30; TBL3; MYBBP1A; NCOR1; HDAC3; RBL1; RBBP7; RBBP4; HDAC1; CDK9; VDR; DEDD2; RBFOX2; IRF9; ZNF232; SNAPC1; PPARG; HOXC13; NR3C1; ELAVL2; POLR3D; RARA; NR1D1; CRX; RXRB; RXRA;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-NR2E3 (ARP39069_T100) antibody
Blocking Peptide For anti-NR2E3 (ARP39069_T100) antibody is Catalog # AAP39069 (Previous Catalog # AAPS04208)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human NR2E3
Uniprot ID Q9Y5X4
Protein Name Photoreceptor-specific nuclear receptor
Publications

Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 7, 10662 (2017). 28878246

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Mol Med. 4, 52-67 (2012). 22174013

Protein Accession # NP_055064
Purification Protein A purified
Nucleotide Accession # NM_014249
Tested Species Reactivity Human
Gene Symbol NR2E3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Pig
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 86%; Human: 100%; Mouse: 93%; Pig: 79%; Rat: 93%
Image 1
Human HepG2
WB Suggested Anti-NR2E3 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate
 

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