CNOT7 Antibody - N-terminal region (ARP39026_P050)

Data Sheet
 
Product Number ARP39026_P050
Product Page www.avivasysbio.com/cnot7-antibody-n-terminal-region-arp39026-p050.html
Name CNOT7 Antibody - N-terminal region (ARP39026_P050)
Protein Size (# AA) 262 amino acids
Molecular Weight 30kDa
Subunit 7
NCBI Gene Id 29883
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name CCR4-NOT transcription complex, subunit 7
Alias Symbols CAF1, CAF-1, Caf1a, hCAF-1
Peptide Sequence Synthetic peptide located within the following region: TEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPP
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kimura,K., (2006) Genome Res. 16 (1), 55-65
Description of Target CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs.The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Protein Interactions FBXW11; TOB2; BTG2; FOXC2; UBC; BAG3; CNOT6; AGO2; AGO1; EPAS1; APP; ELAVL1; BTG1; Cnot3; HOXD4; IKBKG; BTG3; TOB1; CDK6; CDK4; CDK2; CDK1; PABPC1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CNOT7 (ARP39026_P050) antibody
Blocking Peptide For anti-CNOT7 (ARP39026_P050) antibody is Catalog # AAP39026 (Previous Catalog # AAPS03806)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CNOT7
Uniprot ID Q9UIV1
Protein Name CCR4-NOT transcription complex subunit 7
Publications

Maragozidis, P. et al. Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker. Acta Haematol. 128, 39-46 (2012). 22614729

Sample Type Confirmation

CNOT7 is supported by BioGPS gene expression data to be expressed in HepG2

Protein Accession # NP_037486
Purification Affinity Purified
Nucleotide Accession # NM_013354
Tested Species Reactivity Human
Gene Symbol CNOT7
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100%
Image 1
Human HepG2
WB Suggested Anti-CNOT7 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysateCNOT7 is supported by BioGPS gene expression data to be expressed in HepG2
Image 2
Human Heart
Rabbit Anti-CNOT7 antibody
Catalog Number: ARP39026
Paraffin Embedded Tissue: Human Heart
cell Cellular Data: cardiac cell
Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X
 

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