IKZF3 Antibody - N-terminal region (ARP39004_P050)

Data Sheet
 
Product Number ARP39004_P050
Product Page www.avivasysbio.com/ikzf3-antibody-n-terminal-region-arp39004-p050.html
Name IKZF3 Antibody - N-terminal region (ARP39004_P050)
Protein Size (# AA) 453 amino acids
Molecular Weight 52kDa
NCBI Gene Id 22806
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name IKAROS family zinc finger 3 (Aiolos)
Alias Symbols AIO, AIOLOS, ZNFN1A3
Peptide Sequence Synthetic peptide located within the following region: KSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Koipally,J. (2002) J. Biol. Chem. 277 (31), 27697-27705
Description of Target IKZF3 is a member of the Ikaros family of zinc-finger proteins. It is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Protein Interactions STAMBPL1; EXOSC5; LGALS14; CABP5; PCID2; RCOR3; TBC1D22B; FANCL; MAGOHB; C1orf109; OAZ3; SPG21; CHCHD2; OSGIN1; POLM; PPP1R16B; ABLIM3; IKZF3; NEK6; FARS2; MRPL28; KAT5; BCAS2; AKAP9; FAM115A; EMC2; POLR1C; STX11; STK16; RAD51D; PSMA1; PRKAB2; PRKAA1; PIN
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-IKZF3 (ARP39004_P050) antibody
Blocking Peptide For anti-IKZF3 (ARP39004_P050) antibody is Catalog # AAP39004 (Previous Catalog # AAPS03701)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human IKZF3
Uniprot ID Q9UKT9-2
Protein Name Zinc finger protein Aiolos
Protein Accession # NP_899051
Purification Affinity Purified
Nucleotide Accession # NM_183228
Tested Species Reactivity Human
Gene Symbol IKZF3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Pig, Rabbit
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 86%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 86%; Rat: 86%
Image 1
Human Liver
Human Liver
Image 2
Human 786-0
Host: Rabbit
Target Name: IKZF3
Sample Tissue: Human 786-0
Antibody Dilution: 1.0ug/ml
 

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