Product Number |
ARP39004_P050 |
Product Page |
www.avivasysbio.com/ikzf3-antibody-n-terminal-region-arp39004-p050.html |
Name |
IKZF3 Antibody - N-terminal region (ARP39004_P050) |
Protein Size (# AA) |
453 amino acids |
Molecular Weight |
52kDa |
NCBI Gene Id |
22806 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
IKAROS family zinc finger 3 (Aiolos) |
Alias Symbols |
AIO, AIOLOS, ZNFN1A3 |
Peptide Sequence |
Synthetic peptide located within the following region: KSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Koipally,J. (2002) J. Biol. Chem. 277 (31), 27697-27705 |
Description of Target |
IKZF3 is a member of the Ikaros family of zinc-finger proteins. It is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. |
Protein Interactions |
STAMBPL1; EXOSC5; LGALS14; CABP5; PCID2; RCOR3; TBC1D22B; FANCL; MAGOHB; C1orf109; OAZ3; SPG21; CHCHD2; OSGIN1; POLM; PPP1R16B; ABLIM3; IKZF3; NEK6; FARS2; MRPL28; KAT5; BCAS2; AKAP9; FAM115A; EMC2; POLR1C; STX11; STK16; RAD51D; PSMA1; PRKAB2; PRKAA1; PIN |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-IKZF3 (ARP39004_P050) antibody |
Blocking Peptide |
For anti-IKZF3 (ARP39004_P050) antibody is Catalog # AAP39004 (Previous Catalog # AAPS03701) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human IKZF3 |
Uniprot ID |
Q9UKT9-2 |
Protein Name |
Zinc finger protein Aiolos |
Protein Accession # |
NP_899051 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_183228 |
Tested Species Reactivity |
Human |
Gene Symbol |
IKZF3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Pig, Rabbit |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 86%; Rat: 86% |
Image 1 | Human Liver
| Human Liver |
| Image 2 | Human 786-0
| Host: Rabbit Target Name: IKZF3 Sample Tissue: Human 786-0 Antibody Dilution: 1.0ug/ml |
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