| Product Number |
ARP39001_P050 |
| Product Page |
www.avivasysbio.com/stat5b-antibody-c-terminal-region-arp39001-p050.html |
| Name |
STAT5B Antibody - C-terminal region (ARP39001_P050) |
| Protein Size (# AA) |
787 amino acids |
| Molecular Weight |
90kDa |
| NCBI Gene Id |
6777 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Signal transducer and activator of transcription 5B |
| Alias Symbols |
STAT5, GHISID2 |
| Peptide Sequence |
Synthetic peptide located within the following region: GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Mohankumar,K.M., (2008) Endocrinology 149 (5), 2219-2229 |
| Description of Target |
STAT5B is a member of the STAT family of transcription factors. In response to cytokines andgrowth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
JAK2; KIT; SURF2; AARS; DPP9; NIF3L1; RPRD1B; ANKMY2; RPRD1A; TOM1L1; DMRTA1; AFTPH; SERTAD1; HAX1; TFG; VCAM1; UBC; INSR; IL15; APP; C18orf8; STAT5B; PRLR; PGR; FGFR2; POU2F1; ELP2; CENPJ; PPP2CA; STAP2; RARA; PTPN2; NMI; EP300; CRKL; STAT5A; GHR; NCOR2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-STAT5B (ARP39001_P050) antibody |
| Additional Information |
IHC Information: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
IHC Information: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) |
| Blocking Peptide |
For anti-STAT5B (ARP39001_P050) antibody is Catalog # AAP39001 (Previous Catalog # AAPS04610) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human STAT5B |
| Uniprot ID |
P51692 |
| Protein Name |
Signal transducer and activator of transcription 5B |
| Protein Accession # |
NP_036580 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_012448 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
STAT5B |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 79%; Dog: 79%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86% |
| Image 1 | Human Fetal Brain
 | WB Suggested Anti-STAT5B Antibody Titration: 1 ug/ml
Positive Control: Fetal Brain Lysate |
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| Image 2 | |
| Image 3 | |
