| Product Number |
ARP38669_T100 |
| Product Page |
www.avivasysbio.com/nr1h3-antibody-n-terminal-region-arp38669-t100.html |
| Name |
NR1H3 Antibody - N-terminal region (ARP38669_T100) |
| Protein Size (# AA) |
447 amino acids |
| Molecular Weight |
50kDa |
| NCBI Gene Id |
10062 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Nuclear receptor subfamily 1, group H, member 3 |
| Alias Symbols |
LXRA, LXR-a, RLD-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Albers,M., et al., (2006) J. Biol. Chem. 281 (8), 4920-4930 |
| Description of Target |
Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis. |
| Protein Interactions |
RXRG; RXRB; MDFI; SUV39H1; KDM1A; BARD1; MSTO1; HSP90AA1; PIAS1; APP; NR3C1; MYC; ZXDC; TMEM161A; ING3; NCOA6; NCOR1; KAT2B; EIF3I; NRIP1; NCOA3; SRC; RXRA; FOXO3; ACTN1; SS18L1; LZTR1; EDF1; RARA; NR0B2; SYT1; PPARA; SIRT1; UBC; CEP350; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NR1H3 (ARP38669_T100) antibody |
| Blocking Peptide |
For anti-NR1H3 (ARP38669_T100) antibody is Catalog # AAP38669 (Previous Catalog # AAPP20858) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human NR1H3 |
| Uniprot ID |
Q13133 |
| Protein Name |
Oxysterols receptor LXR-alpha |
| Protein Accession # |
NP_005684 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005693 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NR1H3 |
| Predicted Species Reactivity |
Human, Cow, Dog, Goat, Horse, Pig, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 79%; Goat: 85%; Horse: 79%; Human: 100%; Pig: 77%; Rabbit: 86% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-NR1H3 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate |
|
