ETS2 Antibody - middle region (ARP38592_P050)

• Product Number: ARP38592_P050
• Name: ETS2 Antibody - middle region (ARP38592_P050)
• Protein Size (# AA): 469 amino acids
• Molecular Weight: 53kDa
• NCBI Gene Id: 2114
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
• Alias Symbols: ETS2IT1
• Peptide Sequence: Synthetic peptide located within the following region: DPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVC
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Ge,Y., (2008) Leukemia 22 (3), 521-529
• Description of Target: ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: UBC; RFWD2; TWIST1; POU5F1; TWIST2; ZFYVE9; SRA1; XPO1; TP53; SUMO2; EP300; CREBBP; NCOR1; NCOA3; SRC; ZMYND11; TDP2; STAT5B; CDK10; SMARCA4; JUN; ERG; ETS2; ETS1; NR3C1; GATA3; FOS; SPI1; BRCA1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-ETS2 (ARP38592_P050) antibody is Catalog # AAP38592 (Previous Catalog # AAPP23407)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ETS2
• Uniprot ID: P15036
• Protein Name: Protein C-ets-2
• Protein Accession #: NP_005230
• Purification: Affinity Purified
• Nucleotide Accession #: NM_005239
• Tested Species Reactivity: Human, Mouse
• Gene Symbol: ETS2
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
• Image 1: Human kidney
  
  WB Suggested Anti-ETS2 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:312500
  Positive Control: Human kidney
• Image 2: Mouse Heart
  
  Host: Mouse
  Target Name: ETS2
  Sample Tissue: Mouse Heart
  Antibody Dilution: 1ug/ml
• Image 3: human LCL, mouse brains
  
  ETS2 antibody - middle region (ARP38592_P050) validated by WB using human LCL and mouse brains at 1:1000.
• Image 4: Mouse Kidney , Mouse Testis
  
  Host: Rabbit
  Target: ETS2
  Positive control (+): Mouse Kidney (M-KI)
  Negative control (-): Mouse Testis (M-TE)
  Antibody concentration: 1ug/ml