| Product Number |
ARP38530_T100 |
| Product Page |
www.avivasysbio.com/hdac1-antibody-c-terminal-region-arp38530-t100.html |
| Name |
HDAC1 Antibody - C-terminal region (ARP38530_T100) |
| Protein Size (# AA) |
482 amino acids |
| Molecular Weight |
55kDa |
| NCBI Gene Id |
3065 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Histone deacetylase 1 |
| Alias Symbols |
HD1, RPD3, KDAC1, GON-10, RPD3L1 |
| Peptide Sequence |
Synthetic peptide located within the following region: SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Hsu,M.C., et al., (2006) J. Biol. Chem. 281 (8), 4718-4725 |
| Description of Target |
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC1 also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. |
| Protein Interactions |
BCL6; CUL4B; YY1; SIN3A; RCOR1; KDM1A; KAT5; NCOR2; SUMO1; DDIT3; DDB1; BCOR; SF3A1; TP53; SP1; SUMO2; NFKB1; NFE2L2; MDM2; SMAD3; SMAD1; JUN; CHFR; HIF1A; HDAC2; EP300; SAP130; UBC; RELA; RB1; RARA; PRDM6; HAUS2; FEZF2; BANP; WHSC1; ESR1; DNMT3B; DNMT1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-HDAC1 (ARP38530_T100) antibody |
| Blocking Peptide |
For anti-HDAC1 (ARP38530_T100) antibody is Catalog # AAP38530 (Previous Catalog # AAPP20721) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC1 |
| Uniprot ID |
Q13547 |
| Protein Name |
Histone deacetylase 1 |
| Protein Accession # |
NP_004955 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_004964 |
| Tested Species Reactivity |
Human, Mouse, Rat |
| Gene Symbol |
HDAC1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Yeast: 91%; Zebrafish: 77% |
| Image 1 | Rat
 | WB Suggested Anti-HDAC1 Antibody
Titration: 1 ug/ml
Positive Control: Rat tissue |
|
| Image 2 | Human Thymus
 | WB Suggested Anti-HDAC1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: Human Thymus |
|
| Image 3 | mouse brain
 | WB Suggested Anti-HDAC1 Antibody
Positive Control: Lane 1: 5ug mouse brain cytoplasm Lane 2: 5ug mouse brain nucleus
Primary Antibody Dilution : 1:1000
Secondary Antibody : Anti rabbit - IR-dye
Secondry Antibody Dilution : 1:10,000
Submitted by: Anonymous |
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