| Product Number |
ARP38448_T100 |
| Product Page |
www.avivasysbio.com/rnf14-antibody-c-terminal-region-arp38448-t100.html |
| Name |
RNF14 Antibody - C-terminal region (ARP38448_T100) |
| Protein Size (# AA) |
474 amino acids |
| Molecular Weight |
52kDa |
| NCBI Gene Id |
9604 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Ring finger protein 14 |
| Alias Symbols |
ARA54, HFB30, TRIAD2, HRIHFB2038 |
| Peptide Sequence |
Synthetic peptide located within the following region: CMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lin,D.Y., (2004) Mol. Cell. Biol. 24 (24), 10529-10541 |
| Description of Target |
RNF14 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins.The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported. |
| Protein Interactions |
UBE2E2; UBE2D1; DACH1; UBE2D4; LEF1; TCF3; HNF1A; TCF4; CTNNB1; UBC; AR; FAM46A; TNFAIP3; ECT2; UBE2E3; UBE2E1; PHF7; TAGLN; HNRNPA1; VDR; UBE2D3; UBE2D2; UBE2U; UBE2W; UBE2V1; NCOA4; NR3C1; ESR1; RNF14; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RNF14 (ARP38448_T100) antibody |
| Blocking Peptide |
For anti-RNF14 (ARP38448_T100) antibody is Catalog # AAP38448 (Previous Catalog # AAPP23161) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human RNF14 |
| Uniprot ID |
Q9UBS8 |
| Protein Name |
E3 ubiquitin-protein ligase RNF14 |
| Protein Accession # |
NP_899648 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_183401 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RNF14 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 79%; Dog: 79%; Human: 100%; Rabbit: 79%; Rat: 79% |
| Image 1 | Human kidney
 | Human kidney |
|
| Image 2 | Human Jurkat
 | WB Suggested Anti-RNF14 Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysate |
|
