ZFP36 Antibody - N-terminal region (ARP38303_P050)

Data Sheet
 
Product Number ARP38303_P050
Product Page www.avivasysbio.com/zfp36-antibody-n-terminal-region-arp38303-p050.html
Name ZFP36 Antibody - N-terminal region (ARP38303_P050)
Protein Size (# AA) 326 amino acids
Molecular Weight 34kDa
NCBI Gene Id 7538
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Zinc finger protein 36, C3H type, homolog (mouse)
Description
Alias Symbols TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A
Peptide Sequence Synthetic peptide located within the following region: MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSDSSPSGV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Cao,H., et al., (2006) Biochem. J. 394 (PT 1), 285-297
Description of Target ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Protein Interactions YWHAB; PPP2CA; DNAJB1; DCP1B; DHX36; PRR5L; XRN1; UBC; TRAF2; EXOSC6; UPF2; EXOSC8; YWHAQ; TNF; DCP2; EDC3; DCP1A; EDC4; CDK6; APP; LIN28A; SH3KBP1; PABPC1; NCL; MAP3K4; HSPA4; HDAC7; HDAC3; NFKB1; HOXC9; HDAC1; CCDC85B; MAPKAPK2; YWHAG; SFN; HMGB1; NUP21
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ZFP36 (ARP38303_P050) antibody
Blocking Peptide For anti-ZFP36 (ARP38303_P050) antibody is Catalog # AAP38303 (Previous Catalog # AAPP10115)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ZFP36
Uniprot ID P26651
Protein Name Tristetraprolin
Publications

Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. Biomolecules. 5, 2035-55 (2015). 26343742

Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. Cell Mol Gastroenterol Hepatol. 11, 597-621 (2020). 32987153

Protein Accession # NP_003398
Purification Affinity Purified
Nucleotide Accession # NM_003407
Tested Species Reactivity Human
Gene Symbol ZFP36
Predicted Species Reactivity Human
Application WB
Predicted Homology Based on Immunogen Sequence Human: 100%
Image 1
Human Lung
WB Suggested Anti-ZFP36 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Lung
 

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