Product Number |
ARP38303_P050 |
Product Page |
www.avivasysbio.com/zfp36-antibody-n-terminal-region-arp38303-p050.html |
Name |
ZFP36 Antibody - N-terminal region (ARP38303_P050) |
Protein Size (# AA) |
326 amino acids |
Molecular Weight |
34kDa |
NCBI Gene Id |
7538 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Zinc finger protein 36, C3H type, homolog (mouse) |
Description |
|
Alias Symbols |
TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A |
Peptide Sequence |
Synthetic peptide located within the following region: MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSDSSPSGV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Cao,H., et al., (2006) Biochem. J. 394 (PT 1), 285-297 |
Description of Target |
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity. |
Protein Interactions |
YWHAB; PPP2CA; DNAJB1; DCP1B; DHX36; PRR5L; XRN1; UBC; TRAF2; EXOSC6; UPF2; EXOSC8; YWHAQ; TNF; DCP2; EDC3; DCP1A; EDC4; CDK6; APP; LIN28A; SH3KBP1; PABPC1; NCL; MAP3K4; HSPA4; HDAC7; HDAC3; NFKB1; HOXC9; HDAC1; CCDC85B; MAPKAPK2; YWHAG; SFN; HMGB1; NUP21 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ZFP36 (ARP38303_P050) antibody |
Blocking Peptide |
For anti-ZFP36 (ARP38303_P050) antibody is Catalog # AAP38303 (Previous Catalog # AAPP10115) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ZFP36 |
Uniprot ID |
P26651 |
Protein Name |
Tristetraprolin |
Publications |
Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. Biomolecules. 5, 2035-55 (2015). 26343742
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. Cell Mol Gastroenterol Hepatol. 11, 597-621 (2020). 32987153 |
Protein Accession # |
NP_003398 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_003407 |
Tested Species Reactivity |
Human |
Gene Symbol |
ZFP36 |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human: 100% |
Image 1 | Human Lung
| WB Suggested Anti-ZFP36 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Lung |
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