STAT6 Antibody - C-terminal region (ARP38257_P050)

Data Sheet
 
Product Number ARP38257_P050
Product Page www.avivasysbio.com/stat6-antibody-c-terminal-region-arp38257-p050.html
Name STAT6 Antibody - C-terminal region (ARP38257_P050)
Protein Size (# AA) 847 amino acids
Molecular Weight 94kDa
NCBI Gene Id 6778
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Signal transducer and activator of transcription 6, interleukin-4 induced
Alias Symbols STAT6B, STAT6C, D12S1644, IL-4-STAT
Peptide Sequence Synthetic peptide located within the following region: TEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Blanchard,C., (2005) Int. J. Biochem. Cell Biol. 37 (12), 2559-2573
Description of Target STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Protein Interactions UBC; IRF4; PDE12; EHD1; USP8; API5; PGGT1B; EP300; TRIM28; JAK3; RCN3; LITAF; IL4R; EEF1A1; VKORC1; PTPN2; STAT2; JAK1; IFNG; IFNAR1; SRXN1; PSAT1; DSTN; SEC24A; AHCYL1; SSSCA1; NUBP2; SH3BGRL; RAD23B; PPM1G; IGBP1; CEBPE; SND1; SUMO2; FCER2; SFPQ; IGHE;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-STAT6 (ARP38257_P050) antibody
Blocking Peptide For anti-STAT6 (ARP38257_P050) antibody is Catalog # AAP38257 (Previous Catalog # AAPP23111)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human STAT6
Uniprot ID P42226
Protein Name Signal transducer and activator of transcription 6
Protein Accession # NP_003144
Purification Affinity Purified
Nucleotide Accession # NM_003153
Tested Species Reactivity Human
Gene Symbol STAT6
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 93%
Image 1
Human Lung Tissue
STAT6 antibody - C-terminal region (ARP38257_P050)
Catalog Number: ARP38257_P050
Formalin Fixed Paraffin Embedded Tissue: Human Lung Tissue
Observed Staining: Cytoplasm of pneumocytes
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Image 2
recombinant STAT6 protein
WB Suggested Anti-STAT6 Antibody Titration: 0.2-1 ug/ml
Positive Control: recombinant STAT6 protein
 

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