JUNB Antibody - C-terminal region (ARP38136_P050)

Data Sheet
 
Product Number ARP38136_P050
Product Page www.avivasysbio.com/junb-antibody-c-terminal-region-arp38136-p050.html
Name JUNB Antibody - C-terminal region (ARP38136_P050)
Protein Size (# AA) 347 amino acids
Molecular Weight 36kDa
NCBI Gene Id 3726
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Jun B proto-oncogene
Alias Symbols AP-1
Peptide Sequence Synthetic peptide located within the following region: VERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQ
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Troen,G., (2004) J Mol Diagn 6 (4), 297-307
Description of Target The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
Protein Interactions BATF; FOS; RFWD2; C19orf68; USP24; TCERG1; ZNF595; PKIA; MAP2; APLP2; FOSL1; DDIT3; ATF3; BATF2; BATF3; TCL1A; FOSL2; NPM1; NEU1; SMAD4; HOXA7; BDNF; ATF4; MAPK6; UBC; TDG; SET; SAT1; MAPK9; BRCA1; SUMO2; Cebpb; EP300; SMURF1; YY1; CREBBP; SMARCA4; JDP2;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-JUNB (ARP38136_P050) antibody
Blocking Peptide For anti-JUNB (ARP38136_P050) antibody is Catalog # AAP38136 (Previous Catalog # AAPP20312)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human JUNB
Uniprot ID P17275
Protein Name Transcription factor jun-B
Protein Accession # NP_002220
Purification Affinity Purified
Nucleotide Accession # NM_002229
Tested Species Reactivity Human
Gene Symbol JUNB
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Yeast, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 85%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 85%; Rat: 100%; Sheep: 100%; Yeast: 91%; Zebrafish: 85%
Image 1
Transfected 293T
WB Suggested Anti-JUNB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Transfected 293T
 

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