Product Number |
ARP38135_T100 |
Product Page |
www.avivasysbio.com/junb-antibody-n-terminal-region-arp38135-t100.html |
Name |
JUNB Antibody - N-terminal region (ARP38135_T100) |
Protein Size (# AA) |
347 amino acids |
Molecular Weight |
36kDa |
NCBI Gene Id |
3726 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Jun B proto-oncogene |
Alias Symbols |
AP-1 |
Peptide Sequence |
Synthetic peptide located within the following region: YGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGGGGSYF |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Troen,G., (2004) J Mol Diagn 6 (4), 297-307 |
Description of Target |
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. |
Protein Interactions |
BATF; FOS; RFWD2; C19orf68; USP24; TCERG1; ZNF595; PKIA; MAP2; APLP2; FOSL1; DDIT3; ATF3; BATF2; BATF3; TCL1A; FOSL2; NPM1; NEU1; SMAD4; HOXA7; BDNF; ATF4; MAPK6; UBC; TDG; SET; SAT1; MAPK9; BRCA1; SUMO2; Cebpb; EP300; SMURF1; YY1; CREBBP; SMARCA4; JDP2; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-JUNB (ARP38135_T100) antibody |
Blocking Peptide |
For anti-JUNB (ARP38135_T100) antibody is Catalog # AAP38135 (Previous Catalog # AAPP20311) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human JUNB |
Uniprot ID |
P17275 |
Protein Name |
Transcription factor jun-B |
Protein Accession # |
NP_002220 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_002229 |
Tested Species Reactivity |
Human |
Gene Symbol |
JUNB |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rat: 93% |
Image 1 | Transfected 293T
| WB Suggested Anti-JUNB Antibody Titration: 1.25ug/ml ELISA Titer: 1:1562500 Positive Control: Transfected 293T |
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Image 2 | Human heart
| Rabbit Anti-JUNB Antibody Catalog Number: ARP38135_T100 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Nucleus Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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