Product Number |
ARP38067_T100 |
Product Page |
www.avivasysbio.com/atf4-antibody-c-terminal-region-arp38067-t100.html |
Name |
ATF4 Antibody - C-terminal region (ARP38067_T100) |
Protein Size (# AA) |
351 amino acids |
Molecular Weight |
39kDa |
NCBI Gene Id |
468 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Activating transcription factor 4 (tax-responsive enhancer element B67) |
Description |
|
Alias Symbols |
CREB2, TXREB, CREB-2, TAXREB67 |
Peptide Sequence |
Synthetic peptide located within the following region: EQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Lassot,I., et al., (2005) J. Biol. Chem. 280 (50), 41537-41545 |
Description of Target |
ATF4s a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. |
Protein Interactions |
GPS2; GOLGA1; EP300; CEBPG; GOLGA8F; GOLGA8EP; GCC1; TRIB3; CCDC106; LDOC1; FBXW11; NDC80; BTRC; BFSP2; DDIT3; CREBBP; NEK6; JUN; FOS; ATF2; CEBPE; CEBPA; ATF4; ATF3; BATF2; CREBZF; BATF3; BATF; CREB3; MAFB; FOSL1; NFE2L2; NFE2; MAF; UBC; TGM2; RPS6; MAP2 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ATF4 (ARP38067_T100) antibody |
Blocking Peptide |
For anti-ATF4 (ARP38067_T100) antibody is Catalog # AAP38067 (Previous Catalog # AAPP20241) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human ATF4 |
Uniprot ID |
P18848 |
Protein Name |
Cyclic AMP-dependent transcription factor ATF-4 |
Publications |
Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One. 10, e0115723 (2015). 25695253 |
Sample Type Confirmation |
ATF4 is supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_001666 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_001675 |
Tested Species Reactivity |
Human |
Gene Symbol |
ATF4 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Yeast |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 93%; Sheep: 93%; Yeast: 82% |
Image 1 | Human Jurkat
| WB Suggested Anti-ATF4 Antibody Titration: 5.0ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysateATF4 is supported by BioGPS gene expression data to be expressed in Jurkat |
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