MTA1 Antibody - C-terminal region (ARP37738_T100)

Data Sheet
 
Product Number ARP37738_T100
Product Page www.avivasysbio.com/mta1-antibody-c-terminal-region-arp37738-t100.html
Name MTA1 Antibody - C-terminal region (ARP37738_T100)
Protein Size (# AA) 430 amino acids
Molecular Weight 47kDa
NCBI Gene Id 9112
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Metastasis associated 1
Peptide Sequence Synthetic peptide located within the following region: MPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNW
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kumar,R., et al., (2002) Nature 418 (6898), 654-658
Description of Target MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. MTA1 was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
Protein Interactions KRT40; LZTS2; IKZF1; SH3GL1; SAT1; RBBP4; MAGEA11; KPNA3; NOTCH2NL; KRTAP10-8; KHDRBS2; SUMO2; SUMO3; DNMT3B; DNMT1; NACC2; UBC; SUZ12; EED; RNF2; HIC1; SOX2; HDAC2; HDAC1; HIST3H3; GATAD2B; MBD3; KDM1A; POLD3; MTA2; NR2C2; NR2C1; CHD4; UBE2I; HIST2H3C; B
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-MTA1 (ARP37738_T100) antibody
Blocking Peptide For anti-MTA1 (ARP37738_T100) antibody is Catalog # AAP37738 (Previous Catalog # AAPP08820)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human MTA1
Uniprot ID Q13330-2
Protein Name Metastasis-associated protein MTA1
Sample Type Confirmation

MTA1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # AAN01613
Purification Protein A purified
Nucleotide Accession # NM_001203258
Tested Species Reactivity Human
Gene Symbol MTA1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Image 1
Human Jurkat
WB Suggested Anti-MTA1 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysateMTA1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
 

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