| Product Number |
ARP36798_P050 |
| Product Page |
www.avivasysbio.com/mdc1-antibody-c-terminal-region-arp36798-p050.html |
| Name |
MDC1 Antibody - C-terminal region (ARP36798_P050) |
| Protein Size (# AA) |
2089 amino acids |
| Molecular Weight |
227kDa |
| NCBI Gene Id |
9656 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Mediator of DNA-damage checkpoint 1 |
| Alias Symbols |
NFBD1 |
| Peptide Sequence |
Synthetic peptide located within the following region: GKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. |
| Protein Interactions |
RPA3; RPA2; RPA1; EED; TOPBP1; RNF8; UBC; LMNA; RAG1; CDC27; NCL; NBN; MRE11A; CSNK2A1; RAD50; CAPZB; CAPZA1; AUP1; ATP2A2; LOC729324; CHAMP1; HNRNPUL2; PGAM5; LSM12; ANAPC16; OSBPL8; DTX2; ZNF251; RBM17; FAM175A; LAS1L; LPCAT1; MYH14; SLC25A22; ZNF768; H |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MDC1 (ARP36798_P050) antibody |
| Blocking Peptide |
For anti-MDC1 (ARP36798_P050) antibody is Catalog # AAP36798 (Previous Catalog # AAPP08672) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1 |
| Uniprot ID |
Q14676 |
| Protein Name |
Mediator of DNA damage checkpoint protein 1 |
| Sample Type Confirmation |
MDC1 is strongly supported by BioGPS gene expression data to be expressed in HepG2 |
| Protein Accession # |
NP_055456 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_014641 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MDC1 |
| Predicted Species Reactivity |
Human, Dog, Guinea Pig |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 86%; Guinea Pig: 92%; Human: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-MDC1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: HepG2 cell lysateMDC1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells |
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