| Product Number |
ARP36652_T100 |
| Product Page |
www.avivasysbio.com/mcm7-antibody-middle-region-arp36652-t100.html |
| Name |
MCM7 Antibody - middle region (ARP36652_T100) |
| Protein Size (# AA) |
719 amino acids |
| Molecular Weight |
81kDa |
| NCBI Gene Id |
4176 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Minichromosome maintenance complex component 7 |
| Alias Symbols |
MCM2, CDC47, P85MCM, P1CDC47, PNAS146, PPP1R104, P1.1-MCM3 |
| Peptide Sequence |
Synthetic peptide located within the following region: HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ren,B., (2006) Oncogene 25 (7), 1090-1098 |
| Description of Target |
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Protein Interactions |
AK8; MIPOL1; C8orf34; USHBP1; MCMBP; CCDC102B; TRIM54; MBIP; UBQLN1; TRIM27; NAB2; KIFC3; GOLGA2; PNMA1; UBC; SP2; HAUS2; CEP250; CEP57; SUMO2; SUMO3; PCNA; STAU1; SUZ12; RNF2; MCM4; MCM2; HSP90AB1; PRMT1; PRRC1; CLUH; TOMM34; TRIM16; HYOU1; BAG3; MIB1; P |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MCM7 (ARP36652_T100) antibody |
| Blocking Peptide |
For anti-MCM7 (ARP36652_T100) antibody is Catalog # AAP36652 (Previous Catalog # AAPS06308) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human MCM7 |
| Uniprot ID |
P33993 |
| Protein Name |
DNA replication licensing factor MCM7 |
| Sample Type Confirmation |
MCM7 is strongly supported by BioGPS gene expression data to be expressed in Daudi |
| Protein Accession # |
NP_005907 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005916 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MCM7 |
| Predicted Species Reactivity |
Human, Rat, Cow, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 92%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Rabbit: 92%; Rat: 92% |
| Image 1 | Human Daudi
 | WB Suggested Anti-MCM7 Antibody Titration: 1.25ug/ml
Positive Control: Daudi cell lysateMCM7 is strongly supported by BioGPS gene expression data to be expressed in Human Daudi cells |
|
| Image 2 | Human kidney
 | Human kidney |
|
