DDX42 Antibody - N-terminal region (ARP36403_P050)

• Product Number: ARP36403_P050
• Name: DDX42 Antibody - N-terminal region (ARP36403_P050)
• Protein Size (# AA): 938 amino acids
• Molecular Weight: 103kDa
• NCBI Gene Id: 11325
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
• Alias Symbols: RHELP, RNAHP, SF3B8, DDX42P, SF3b125
• Peptide Sequence: Synthetic peptide located within the following region: PLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYM
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Will,C.L., et al., (2002) EMBO J. 21 (18), 4978-4988
• Description of Target: DDX42 is a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX42 is a ATP-dependent RNA helicase. DDX42 binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. It also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein.This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.
• Protein Interactions: FUS; UBC; SUMO1; EED; SHFM1; FBXO25; LMNA; PRPF19; U2SURP; SF3A1; SF3B4; SNRPC; ITGA4; DHX15; PIN4; KAL1; EPRS; APP; PHF20; NOSIP; RPL36; FOXJ3; TCERG1; SYNCRIP; RPS6KA4; SUMO3; ISG15; SIRT7; SF3A2; MEPCE; RUVBL2; RUVBL1; RECQL5; SF3B1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-DDX42 (ARP36403_P050) antibody is Catalog # AAP36403 (Previous Catalog # AAPS29814)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DDX42
• Uniprot ID: Q86XP3
• Protein Name: ATP-dependent RNA helicase DDX42
• Protein Accession #: NP_031398
• Purification: Affinity Purified
• Nucleotide Accession #: NM_007372
• Tested Species Reactivity: Human
• Gene Symbol: DDX42
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Image 1: Human Thymus
  
  WB Suggested Anti-DDX42 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:1562500
  Positive Control: Human Thymus