Product Number |
ARP35226_T100 |
Product Page |
www.avivasysbio.com/fxyd5-antibody-middle-region-arp35226-t100.html |
Name |
FXYD5 Antibody - middle region (ARP35226_T100) |
Protein Size (# AA) |
178 amino acids |
Molecular Weight |
20kDa |
NCBI Gene Id |
53827 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
FXYD domain containing ion transport regulator 5 |
Alias Symbols |
RIC, IWU1, KCT1, OIT2, DYSAD, HSPC113, PRO6241 |
Peptide Sequence |
Synthetic peptide located within the following region: DETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTDDTTTLSERPSPST |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Batistatou,A., (2005) Br. J. Cancer 93 (12), 1382-1387 |
Description of Target |
FXYD5 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.This reference sequence was derived from AF161462.1 and ESTs; validated by multiple replicate ESTs and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.]. |
Protein Interactions |
UBC; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-FXYD5 (ARP35226_T100) antibody |
Blocking Peptide |
For anti-FXYD5 (ARP35226_T100) antibody is Catalog # AAP35226 (Previous Catalog # AAPP23895) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human FXYD5 |
Uniprot ID |
Q96DB9 |
Protein Name |
FXYD domain-containing ion transport regulator 5 |
Protein Accession # |
NP_054883 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_014164 |
Tested Species Reactivity |
Human |
Gene Symbol |
FXYD5 |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human: 100% |
Image 1 | Human Jurkat
| WB Suggested Anti-FXYD5 Antibody Titration: 1.25ug/ml Positive Control: Jurkat cell lysate |
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