Product Number |
ARP35123_P050 |
Product Page |
www.avivasysbio.com/vdac2-antibody-n-terminal-region-arp35123-p050.html |
Name |
VDAC2 Antibody - N-terminal region (ARP35123_P050) |
Protein Size (# AA) |
294 amino acids |
Molecular Weight |
32 kDa |
NCBI Gene Id |
7417 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Voltage-dependent anion channel 2 |
Alias Symbols |
POR |
Peptide Sequence |
Synthetic peptide located within the following region: MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Chandra,D., (2005) J. Biol. Chem. 280 (19), 19051-19061 |
Description of Target |
VDAC2 forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. |
Protein Interactions |
MDM2; ADRB2; FBXO6; PARK2; PHKG2; PHB; VCAM1; UBC; ITGA4; FN1; ATF2; env; MDC1; ECT2; ACAA2; TRAP1; ATP6V1F; VDAC3; VDAC1; UBE2L3; UBA52; SSBP1; SCP2; RPN1; MPV17; RPSA; HNRNPU; FLOT2; ELAVL1; DDOST; APP; Htt; ZNF454; SFXN3; THOC6; SUGP1; SEPT11; ZFR; ATP |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
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Datasheets/Manuals |
Printable datasheet for anti-VDAC2 (ARP35123_P050) antibody |
Blocking Peptide |
For anti-VDAC2 (ARP35123_P050) antibody is Catalog # AAP35123 (Previous Catalog # AAPP08406) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human VDAC2 |
Uniprot ID |
P45880-5 |
Protein Name |
Voltage-dependent anion-selective channel protein 2 |
Publications |
Hrabakova, R. et al. Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. J. Proteome Res. 12, 455-69 (2013). 23151231 |
Sample Type Confirmation |
VDAC2 is supported by BioGPS gene expression data to be expressed in HEK293T |
Protein Accession # |
NP_003366 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_003375 |
Tested Species Reactivity |
Human |
Gene Symbol |
VDAC2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 79%; Zebrafish: 86% |
Image 1 | Human Cell Lines
| WB Suggested Anti-VDAC2 Antibody Titration: 1.6 ug/ml Positive Control: human cell lines |
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Image 2 | Human Bronchial Epithelial Tissue
| Rabbit Anti-VDAC2 Antibody Catalog Number: ARP35123_P050 Formalin Fixed Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec
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Image 3 | Human 293T
| WB Suggested Anti-VDAC2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Transfected 293TVDAC2 is supported by BioGPS gene expression data to be expressed in HEK293T |
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