| Product Number |
ARP35095_T100 |
| Product Page |
www.avivasysbio.com/kcnn1-antibody-c-terminal-region-arp35095-t100.html |
| Name |
KCNN1 Antibody - C-terminal region (ARP35095_T100) |
| Protein Size (# AA) |
543 amino acids |
| Molecular Weight |
60kDa |
| NCBI Gene Id |
3780 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 |
| Alias Symbols |
SK1, hSK1, SKCA1, KCa2.1 |
| Peptide Sequence |
Synthetic peptide located within the following region: KIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLD |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Arnold,S.J., et al., (2003) Neuroreport 14 (2), 191-195 |
| Description of Target |
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels. |
| Protein Interactions |
UBC; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-KCNN1 (ARP35095_T100) antibody |
| Blocking Peptide |
For anti-KCNN1 (ARP35095_T100) antibody is Catalog # AAP35095 (Previous Catalog # AAPP08953) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN1 |
| Uniprot ID |
Q6DJU4 |
| Protein Name |
Small conductance calcium-activated potassium channel protein 1 |
| Protein Accession # |
NP_002239 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_002248 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
KCNN1 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Pig: 93%; Rat: 85% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-KCNN1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate |
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