SCNN1B Antibody - C-terminal region (ARP34936_P050)

• Product Number: ARP34936_P050
• Name: SCNN1B Antibody - C-terminal region (ARP34936_P050)
• Protein Size (# AA): 640 amino acids
• Molecular Weight: 70kDa
• Subunit: beta
• NCBI Gene Id: 6338
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Sodium channel, non-voltage-gated 1, beta subunit
• Alias Symbols: BESC1, ENaCb, SCNEB, LIDLS1, ENaCbeta
• Peptide Sequence: Synthetic peptide located within the following region: QPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Snyder,P.M., et al., (2004) J. Biol. Chem. 279 (44), 45753-45758
• Description of Target: When expressed in the bladder epithelium, the protein encoded by the SCNN1B gene might be implicated in the mechanosensory transduction in the bladder afferent pathways, thereby inducing detrusor instability by outlet obstruction. Common variants of this gene confer susceptibility to human essential hypertension.
• Protein Interactions: NEDD4L; SERP1; SCNN1G; SCNN1A; COMMD1; UBC; USP2; RAF1; NEDD4; TSC22D3; SGK1; EPN1; AP1M2; NFASC; CNTN1; WWP2; SCNN1D; ANK3; STX1A; ITCH; HECW1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-SCNN1B (ARP34936_P050) antibody is Catalog # AAP34936 (Previous Catalog # AAPP06159)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SCNN1B
• Uniprot ID: P51168
• Protein Name: Amiloride-sensitive sodium channel subunit beta
• Protein Accession #: NP_000327
• Purification: Affinity Purified
• Nucleotide Accession #: NM_000336
• Tested Species Reactivity: Human
• Gene Symbol: SCNN1B
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 92%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 93%; Rat: 86%
• Image 1: RPMI-8226, U937
  
  Host: Rabbit
  Target: SCNN1B
  Positive control (+): RPMI-8226 (N12)
  Negative control (-): U937 (N31)
  Antibody concentration: 7ug/ml
• Image 2: Human HT-29 Whole Cell
  
  Host: Rabbit
  Target Name: SCNN1B
  Sample Tissue: Human HT-29 Whole Cell
  Antibody Dilution: 5ug/ml
• Image 3: Human Jurkat
  
  WB Suggested Anti-SCNN1B Antibody Titration: 0.125ug/ml
  ELISA Titer: 1:312500
  Positive Control: Jurkat cell lysate
• Image 4: Human A549, H441
  
  A549, H441