CBX3 Antibody - middle region (ARP34722_P050)

Data Sheet
 
Product Number ARP34722_P050
Product Page www.avivasysbio.com/cbx3-antibody-middle-region-arp34722-p050.html
Name CBX3 Antibody - middle region (ARP34722_P050)
Protein Size (# AA) 183 amino acids
Molecular Weight 21kDa
NCBI Gene Id 11335
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Chromobox homolog 3
Alias Symbols HECH, HP1-GAMMA, HP1Hs-gamma
Peptide Sequence Synthetic peptide located within the following region: WEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDA
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Scherer,S.W., et al., (2003) Science 300 (5620), 767-772
Description of Target At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Protein Interactions UBC; SUMO1; MDM2; EED; SUZ12; RNF2; WDR1; DCK; ADSS; THOP1; TALDO1; PTMS; OXCT1; IDH1; HSPE1; HECW2; PARK2; VHL; CHAF1A; AURKB; AURKA; EHMT2; FN1; TRIM39; HNF1A; CBX5; MDC1; TP53BP1; YWHAE; TNKS1BP1; H2AFY; ATXN7L2; CACNB4; BAHD1; CUL1; PCGF6; SIRT7; RYBP
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CBX3 (ARP34722_P050) antibody
Blocking Peptide For anti-CBX3 (ARP34722_P050) antibody is Catalog # AAP34722 (Previous Catalog # AAPP05916)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human CBX3
Uniprot ID Q13185
Protein Name Chromobox protein homolog 3
Sample Type Confirmation

CBX3 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_009207
Purification Affinity Purified
Nucleotide Accession # NM_007276
Tested Species Reactivity Human
Gene Symbol CBX3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Image 1
Human Jurkat
WB Suggested Anti-CBX3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Jurkat cell lysateCBX3 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Image 2
Human Placenta
Rabbit Anti-CBX3 antibody
Catalog Number: ARP34722
Formalin Fixed Paraffin Embedded Tissue: Human Placenta
Primary antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20x
Exposure Time: 0.5-2.0sec
Image 3
Human Testis
Rabbit Anti-CBX3 antibody
Catalog Number: ARP34722
Formalin Fixed Paraffin Embedded Tissue: Human Testis
Primary antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20x
Exposure Time: 0.5-2.0sec
 

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