Product Number |
ARP34722_P050 |
Product Page |
www.avivasysbio.com/cbx3-antibody-middle-region-arp34722-p050.html |
Name |
CBX3 Antibody - middle region (ARP34722_P050) |
Protein Size (# AA) |
183 amino acids |
Molecular Weight |
21kDa |
NCBI Gene Id |
11335 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Chromobox homolog 3 |
Alias Symbols |
HECH, HP1-GAMMA, HP1Hs-gamma |
Peptide Sequence |
Synthetic peptide located within the following region: WEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDA |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Scherer,S.W., et al., (2003) Science 300 (5620), 767-772 |
Description of Target |
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. |
Protein Interactions |
UBC; SUMO1; MDM2; EED; SUZ12; RNF2; WDR1; DCK; ADSS; THOP1; TALDO1; PTMS; OXCT1; IDH1; HSPE1; HECW2; PARK2; VHL; CHAF1A; AURKB; AURKA; EHMT2; FN1; TRIM39; HNF1A; CBX5; MDC1; TP53BP1; YWHAE; TNKS1BP1; H2AFY; ATXN7L2; CACNB4; BAHD1; CUL1; PCGF6; SIRT7; RYBP |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CBX3 (ARP34722_P050) antibody |
Blocking Peptide |
For anti-CBX3 (ARP34722_P050) antibody is Catalog # AAP34722 (Previous Catalog # AAPP05916) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human CBX3 |
Uniprot ID |
Q13185 |
Protein Name |
Chromobox protein homolog 3 |
Sample Type Confirmation |
CBX3 is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_009207 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_007276 |
Tested Species Reactivity |
Human |
Gene Symbol |
CBX3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
Image 1 | Human Jurkat
| WB Suggested Anti-CBX3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Jurkat cell lysateCBX3 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
|
Image 2 | Human Placenta
| Rabbit Anti-CBX3 antibody Catalog Number: ARP34722 Formalin Fixed Paraffin Embedded Tissue: Human Placenta Primary antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20x Exposure Time: 0.5-2.0sec
|
|
Image 3 | Human Testis
| Rabbit Anti-CBX3 antibody Catalog Number: ARP34722 Formalin Fixed Paraffin Embedded Tissue: Human Testis Primary antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20x Exposure Time: 0.5-2.0sec
|
|