HDAC8 Antibody - C-terminal region (ARP34587_P050)

• Product Number: ARP34587_P050
• Name: HDAC8 Antibody - C-terminal region (ARP34587_P050)
• Protein Size (# AA): 377 amino acids
• Molecular Weight: 99 kDa
• NCBI Gene Id: 55869
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Histone deacetylase 8
• Alias Symbols: HD8, WTS, RPD3, CDA07, CDLS5, KDAC8, MRXS6, HDACL1
• Peptide Sequence: Synthetic peptide located within the following region: TGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNY
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Lee,H., et al., (2004) Mol. Cell. Biol. 24 (2), 765-773
• Description of Target: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: MDM1; HDAC8; ZSCAN2; CHCHD3; STAG2; SEC16A; CROCC; SMC3; CPNE3; SMC1A; TPM4; TPM3; SVIL; NUP98; MME; ADD3; SMG5; SMG6; HSP90AA1; HSPA4; HIST4H4; HIST3H3; UBC; PRKACA; HIST1H4A; HIST1H3A; ESRRA; ACTA1; RTN1; PPP1CC; CREB1; HIST2H4A; RUNX1T1; CBFA2T3; MDC1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation: Relative Expression (Western Blot)
  
• Blocking Peptide: For anti-HDAC8 (ARP34587_P050) antibody is Catalog # AAP34587 (Previous Catalog # AAPS28704)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC8
• Uniprot ID: Q9BY41
• Protein Name: Histone deacetylase 8
• Protein Accession #: NP_060956
• Purification: Affinity Purified
• Nucleotide Accession #: NM_018486
• Tested Species Reactivity: Human
• Gene Symbol: HDAC8
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Image 1: Human Jurkat
  
  WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:1562500
  Positive Control: Jurkat cell lysate