NFKBIB Antibody - C-terminal region (ARP34504_T100)

• Product Number: ARP34504_T100
• Name: NFKBIB Antibody - C-terminal region (ARP34504_T100)
• Protein Size (# AA): 356 amino acids
• Molecular Weight: 38kDa
• NCBI Gene Id: 4793
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
• Alias Symbols: IKBB, TRIP9
• Peptide Sequence: Synthetic peptide located within the following region: MLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVV
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Joo,M., (2005) J. Virol. 79 (12), 7648-7657
• Description of Target: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].
• Protein Interactions: VPS52; UBC; BAG3; TSPAN1; GIT2; RELA; REL; CSNK2A1; CDC25A; BAK1; APP; ZBTB7A; DNAJA3; IKBKB; CHUK; BRAP; IKBKG; TRE17; NFKBIA; NCOR2; PPARG; ESR2; POLR1D; POLR1E; POLR1A; POLR1C; POLR2H; NKIRAS2; POLR1B; NKIRAS1; LRPPRC; RASAL2; MTIF2; BTRC; CUL1; SKP1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-NFKBIB (ARP34504_T100) antibody is Catalog # AAP34504 (Previous Catalog # AAPY00526)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NFKBIB
• Uniprot ID: Q15653
• Protein Name: NF-kappa-B inhibitor beta
• Sample Type Confirmation:

  NFKBIB is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_002494
• Purification: Protein A purified
• Nucleotide Accession #: NM_002503
• Tested Species Reactivity: Human
• Gene Symbol: NFKBIB
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 91%; Dog: 83%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 85%; Rabbit: 77%; Rat: 92%
• Image 1: Human Jurkat
  
  WB Suggested Anti-NFKBIB Antibody Titration: 5.0ug/ml
  ELISA Titer: 1:312500
  Positive Control: Jurkat cell lysateNFKBIB is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
• Image 2: Human Intestine
  
  Human Intestine