ATG4B Antibody - C-terminal region (ARP34434_T100)

• Product Number: ARP34434_T100
• Name: ATG4B Antibody - C-terminal region (ARP34434_T100)
• Protein Size (# AA): 393 amino acids
• Molecular Weight: 44kDa
• NCBI Gene Id: 23192
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: ATG4 autophagy related 4 homolog B (S. cerevisiae)
• Alias Symbols: APG4B, AUTL1
• Peptide Sequence: Synthetic peptide located within the following region: LGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEIL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Kumanomidou,T., (2006) J. Mol. Biol. 355 (4), 612-618
• Description of Target: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. APG4B encodes a member of the autophagin protein family and is also designated as a member of the C-54 family of cysteine proteases.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Protein Interactions: SUMO2; MAP1LC3B; MAP1LC3A; BAG3; ATG8; YWHAB; GABARAPL1; SQSTM1; UBC; GABARAPL2; ATG10; ATG3; AMBRA1; GABARAP; CAMKK2; ATG12; ULK1; STK3; KRT4; ANXA1; FBXW11; LINC00341;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-ATG4B (ARP34434_T100) antibody is Catalog # AAP34434
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ATG4B
• Uniprot ID: Q9Y4P1
• Protein Name: Cysteine protease ATG4B
• Sample Type Confirmation:

  ATG4B is strongly supported by BioGPS gene expression data to be expressed in Raji

• Protein Accession #: NP_037457
• Purification: Protein A purified
• Nucleotide Accession #: NM_013325
• Tested Species Reactivity: Human
• Gene Symbol: ATG4B
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
• Image 1: Human Raji
  
  WB Suggested Anti-ATG4B Antibody
  Titration: 2.5 ug/ml
  Positive Control: RajiATG4B is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells