| Product Number |
ARP34122_T100 |
| Product Page |
www.avivasysbio.com/lig4-antibody-n-terminal-region-arp34122-t100.html |
| Name |
LIG4 Antibody - N-terminal region (ARP34122_T100) |
| Protein Size (# AA) |
911 amino acids |
| Molecular Weight |
104kDa |
| NCBI Gene Id |
3981 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Ligase IV, DNA, ATP-dependent |
| Alias Symbols |
LIG4S |
| Peptide Sequence |
Synthetic peptide located within the following region: DGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQ |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Smith,J., et al., (2003) Nucleic Acids Res. 31 (8), 2157-2167 |
| Description of Target |
LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. |
| Protein Interactions |
XRCC4; UBC; AGO2; GZMK; ZSCAN18; PHF10; PNKP; TSFM; PRKDC; GUSBP3; NOMO3; FBLL1; PGP; ASPM; AMZ2P1; PPP1R18; COMMD1; ZNF428; AGAP4; WDR20; RPS19BP1; ZFAND2A; FIP1L1; CCDC176; VKORC1; COA7; SOWAHC; SEMA4G; ALMS1; WARS; UBE2L3; UBB; TPT1; TPI1; TP53BP1; TLE |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-LIG4 (ARP34122_T100) antibody |
| Blocking Peptide |
For anti-LIG4 (ARP34122_T100) antibody is Catalog # AAP34122 (Previous Catalog # AAPP05331) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human LIG4 |
| Uniprot ID |
Q8IY66 |
| Protein Name |
DNA ligase 4 |
| Protein Accession # |
NP_002303 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_002312 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
LIG4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 92%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93% |
| Image 1 | Human Pancreas
 | Human Pancreas |
|
| Image 2 | Human Fetal Liver
 | Host: Rabbit
Target Name: LIG4
Sample Tissue: Human Fetal Liver
Antibody Dilution: 1.0ug/ml |
|
