| Product Number |
ARP33991_P050 |
| Product Page |
www.avivasysbio.com/ncoa1-antibody-middle-region-arp33991-p050.html |
| Name |
NCOA1 Antibody - middle region (ARP33991_P050) |
| Protein Size (# AA) |
1399 amino acids |
| Molecular Weight |
152kDa |
| NCBI Gene Id |
8648 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Nuclear receptor coactivator 1 |
| Alias Symbols |
SRC1, KAT13A, RIP160, F-SRC-1, bHLHe42, bHLHe74 |
| Peptide Sequence |
Synthetic peptide located within the following region: GLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lavery,D.N. (2008) Biochemistry 47 (11), 3352-3359 |
| Description of Target |
NCOA1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. NCOA1 binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion.The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Protein Interactions |
ASCC1; NR1I2; PPARG; AR; VDR; THRB; RXRA; RORB; RORA; RARA; HNF4G; NR6A1; NR5A2; ESRRA; ESR1; PAGR1; Esr2; NR3C1; CXADR; PPARA; AHR; KANK2; NCOA2; TRIM24; NCOA1; ANIB1; PGR; COPS5; UBE2L3; TP53; NCOA6; EP300; UBC; RARB; PPARD; RARG; RBBP6; CREBBP; STAT3; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NCOA1 (ARP33991_P050) antibody |
| Blocking Peptide |
For anti-NCOA1 (ARP33991_P050) antibody is Catalog # AAP33991 (Previous Catalog # AAPP05066) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NCOA1 |
| Uniprot ID |
Q15788-2 |
| Protein Name |
Nuclear receptor coactivator 1 |
| Protein Accession # |
NP_671756 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_147223 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NCOA1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100% |
| Image 1 | Human NCI-H226
 | WB Suggested Anti-NCOA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: NCI-H226 cell lysate |
|
