Product Number |
ARP33489_P050 |
Product Page |
www.avivasysbio.com/nsd2-antibody-n-terminal-region-arp33489-p050.html |
Name |
NSD2 Antibody - N-terminal region (ARP33489_P050) |
Protein Size (# AA) |
802 amino acids |
Molecular Weight |
88kDa |
NCBI Gene Id |
7468 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
nuclear receptor binding SET domain protein 2 |
Alias Symbols |
WHS, TRX5, KMT3F, KMT3G, MMSET, WHSC1, REIIBP |
Peptide Sequence |
Synthetic peptide located within the following region: KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFG |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Santra,M., et al., (2003) Blood 101 (6), 2374-2376 |
Description of Target |
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. |
Protein Interactions |
HIST1H3A; HIST3H3; HDAC1; TRIM28; UBC; SF3A1; HNRNPR; MPHOSPH10; RAD50; SART3; NUP93; GTF3C4; NOLC1; DDX21; BAZ1B; DDX18; KHSRP; RRP1; SMARCA5; SMC1A; RBM10; XRCC5; VIM; EZR; TOP2B; TOP1; TMPO; SMARCA4; SFPQ; RPN1; RBBP4; RANGAP1; PTBP1; PRKDC; PLRG1; PKP |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-NSD2 (ARP33489_P050) antibody |
Blocking Peptide |
For anti-NSD2 (ARP33489_P050) antibody is Catalog # AAP33489 (Previous Catalog # AAPP04539) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human WHSC1 |
Uniprot ID |
O96031 |
Protein Name |
histone-lysine N-methyltransferase NSD2 |
Publications |
Li, J. et al. Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas. Neuro. Oncol. 10, 45-51 (2008). 18182627 |
Sample Type Confirmation |
There is BioGPS gene expression data showing that WHSC1 is expressed in HepG2 |
Protein Accession # |
NP_055734 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_014919 |
Tested Species Reactivity |
Human |
Gene Symbol |
NSD2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 93%; Guinea Pig: 88%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 76%; Rat: 86% |
Image 1 | Human HepG2
| WB Suggested Anti-WHSC1 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that WHSC1 is expressed in HepG2 |
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