| Product Number |
ARP33414_P050 |
| Product Page |
www.avivasysbio.com/tcf7l2-antibody-middle-region-arp33414-p050.html |
| Name |
TCF7L2 Antibody - middle region (ARP33414_P050) |
| Protein Size (# AA) |
596 amino acids |
| Molecular Weight |
65kDa |
| NCBI Gene Id |
6934 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Transcription factor 7-like 2 (T-cell specific, HMG-box) |
| Alias Symbols |
TCF4, TCF-4 |
| Peptide Sequence |
Synthetic peptide located within the following region: GGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ren,Q., (2008) Diabetologia 51 (7), 1146-1152 |
| Description of Target |
The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605 |
| Protein Interactions |
UBC; FBLN1; UBE2I; PSMA3; MAD2L2; ZBTB33; DAXX; CTNNB1; ELAVL1; PARP1; XRCC5; SUMO2; XRCC6; NR5A1; EP300; CEBPA; CTBP1; DAZAP2; CTNNBIP1; JUP; CSNK2A2; CSNK2A1; PSEN1; NLK; RAC1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-TCF7L2 (ARP33414_P050) antibody |
| Blocking Peptide |
For anti-TCF7L2 (ARP33414_P050) antibody is Catalog # AAP33414 (Previous Catalog # AAPP04460) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human TCF7L2 |
| Uniprot ID |
Q6FHW4 |
| Protein Name |
TCF7L2 protein EMBL CAG38811.1 |
| Protein Accession # |
NP_110383 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_030756 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
TCF7L2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 92%; Human: 92%; Mouse: 92%; Rabbit: 92%; Rat: 92%; Zebrafish: 92% |
| Image 1 | Hum. Fetal Heart
 | Hum. Fetal Heart |
|
| Image 2 | Hum. Fetal Lung
 | Hum. Fetal Lung |
|
| Image 3 | Hum. Fetal Liver
 | Hum. Fetal Liver |
|
| Image 4 | Human Muscle
 | WB Suggested Anti-TCF7L2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: Human Muscle |
|
