TBX3 Antibody - middle region (ARP33412_T100)

• Product Number: ARP33412_T100
• Name: TBX3 Antibody - middle region (ARP33412_T100)
• Protein Size (# AA): 600 amino acids
• Molecular Weight: 66kDa
• NCBI Gene Id: 6926
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: T-box 3
• Alias Symbols: UMS, XHL, TBX3-ISO
• Peptide Sequence: Synthetic peptide located within the following region: CRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEE
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: et al., ()
• Description of Target: TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
• Protein Interactions: CA8; AES; SOX2; Dlg4; ELAVL1; HDAC5; HDAC3; HDAC2; HDAC1; TOLLIP; TBX3;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-TBX3 (ARP33412_T100) antibody is Catalog # AAP33412 (Previous Catalog # AAPP04458)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TBX3
• Uniprot ID: O15119-3
• Protein Name: T-box transcription factor TBX3
• Publications:

  Bozyk, P. D. et al. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Stem Cells Dev. 20, 1995-2007 (2011). 21341990

  Yano, T. et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J. Cell Biol. 193, 319-32 (2011). 21482718

• Sample Type Confirmation:

  TBX3 is supported by BioGPS gene expression data to be expressed in HepG2

• Purification: Protein A purified
• Tested Species Reactivity: Human
• Gene Symbol: TBX3
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Image 1: Human HepG2
  
  WB Suggested Anti-TBX3 Antibody Titration: 1.25ug/ml
  Positive Control: HepG2 cell lysateTBX3 is supported by BioGPS gene expression data to be expressed in HepG2
• Image 2: Human
  
  Sample Type: human iPS cells and 293T cell lysatePrimary Dilution: 1.25ug/mL