MMP9 Antibody - N-terminal region (ARP33090_T100)

Data Sheet
 
Product Number ARP33090_T100
Product Page www.avivasysbio.com/mmp9-antibody-n-terminal-region-arp33090-t100.html
Name MMP9 Antibody - N-terminal region (ARP33090_T100)
Protein Size (# AA) 707 amino acids
Molecular Weight 78 kDa
NCBI Gene Id 4318
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Alias Symbols GELB, CLG4B, MMP-9, MANDP2
Peptide Sequence Synthetic peptide located within the following region: VAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Nozell,S., et al., (2004) J. Biol. Chem. 279 (37), 38577-38589
Description of Target Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Protein Interactions CXCL5; PZP; MMP26; RECK; KISS1; PRSS2; EPHB2; BTC; LCN2; COL4A6; COL4A5; TIMP3; THBS2; THBS1; MMP10; MMP7; PLG; CXCL1; TFPI; CXCL8; FN1; MMP9; COL1A2; COL1A1; COL4A4; COL4A1; COL4A2; COL4A3; HAPLN1; CD44; AREG; TGFB1; CXCL6;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
WBY
SPR
YCHAROS
Datasheets/Manuals Printable datasheet for anti-MMP9 (ARP33090_T100) antibody
Blocking Peptide For anti-MMP9 (ARP33090_T100) antibody is Catalog # AAP33090 (Previous Catalog # AAPY00103)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MMP9
Uniprot ID P14780
Protein Name Matrix metalloproteinase-9
Publications

Deng, J., Zhang, J., Feng, C., Xiong, L. & Zuo, Z. Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice. Cardiovasc. Res. 103, 473-84 (2014). 24935427

Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins. Reprod Sci. , 1933719117697127 (2017). 28299992

Gotschy, A. et al. Local arterial stiffening assessed by MRI precedes atherosclerotic plaque formation. Circ. Cardiovasc. Imaging 6, 916-23 (2013). 24100044

Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine. Fundam Clin Pharmacol. 30, 47-57 (2016). 26501493

Li, L. et al. DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling. PLoS One 9, e91509 (2014). 24621612

Zhang, J., Jiang, W. & Zuo, Z. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience 261, 1-10 (2014). 24365462

Protein Accession # NP_004985
Purification Protein A purified
Nucleotide Accession # NM_004994
Tested Species Reactivity Human
Gene Symbol MMP9
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
Image 1
Human prostate cancer
MMP9 in humanprostate cancer was detected using HRP/AEC red color stain.
Dilution : 2-15 ug/mL
Image 2
Human Ovary Tumor
Host: Rabbit
Target Name: MMP9
Sample Tissue: Human Ovary Tumor
Antibody Dilution: 1ug/ml
 

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