Product Number |
ARP33090_T100 |
Product Page |
www.avivasysbio.com/mmp9-antibody-n-terminal-region-arp33090-t100.html |
Name |
MMP9 Antibody - N-terminal region (ARP33090_T100) |
Protein Size (# AA) |
707 amino acids |
Molecular Weight |
78 kDa |
NCBI Gene Id |
4318 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
Alias Symbols |
GELB, CLG4B, MMP-9, MANDP2 |
Peptide Sequence |
Synthetic peptide located within the following region: VAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Nozell,S., et al., (2004) J. Biol. Chem. 279 (37), 38577-38589 |
Description of Target |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. |
Protein Interactions |
CXCL5; PZP; MMP26; RECK; KISS1; PRSS2; EPHB2; BTC; LCN2; COL4A6; COL4A5; TIMP3; THBS2; THBS1; MMP10; MMP7; PLG; CXCL1; TFPI; CXCL8; FN1; MMP9; COL1A2; COL1A1; COL4A4; COL4A1; COL4A2; COL4A3; HAPLN1; CD44; AREG; TGFB1; CXCL6; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
|
Datasheets/Manuals |
Printable datasheet for anti-MMP9 (ARP33090_T100) antibody |
Blocking Peptide |
For anti-MMP9 (ARP33090_T100) antibody is Catalog # AAP33090 (Previous Catalog # AAPY00103) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human MMP9 |
Uniprot ID |
P14780 |
Protein Name |
Matrix metalloproteinase-9 |
Publications |
Deng, J., Zhang, J., Feng, C., Xiong, L. & Zuo, Z. Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice. Cardiovasc. Res. 103, 473-84 (2014). 24935427
Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins. Reprod Sci. , 1933719117697127 (2017). 28299992
Gotschy, A. et al. Local arterial stiffening assessed by MRI precedes atherosclerotic plaque formation. Circ. Cardiovasc. Imaging 6, 916-23 (2013). 24100044
Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine. Fundam Clin Pharmacol. 30, 47-57 (2016). 26501493
Li, L. et al. DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling. PLoS One 9, e91509 (2014). 24621612
Zhang, J., Jiang, W. & Zuo, Z. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience 261, 1-10 (2014). 24365462 |
Protein Accession # |
NP_004985 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_004994 |
Tested Species Reactivity |
Human |
Gene Symbol |
MMP9 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100% |
Image 1 | Human prostate cancer
| MMP9 in humanprostate cancer was detected using HRP/AEC red color stain.
Dilution : 2-15 ug/mL |
|
Image 2 | Human Ovary Tumor
| Host: Rabbit Target Name: MMP9 Sample Tissue: Human Ovary Tumor Antibody Dilution: 1ug/ml |
|