| Product Number |
ARP32929_T100 |
| Product Page |
www.avivasysbio.com/psmc3-antibody-middle-region-arp32929-t100.html |
| Name |
PSMC3 Antibody - middle region (ARP32929_T100) |
| Protein Size (# AA) |
439 amino acids |
| Molecular Weight |
45kDa |
| Subunit |
6A |
| NCBI Gene Id |
5702 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
| Alias Symbols |
RPT5, TBP1 |
| Peptide Sequence |
Synthetic peptide located within the following region: TKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILD |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Thompson,H.G., et al., (2004) Int. J. Cancer 111 (3), 338-347 |
| Description of Target |
PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9 |
| Protein Interactions |
AMOTL2; UBC; PSMD9; PSMC6; PSMC3; KDM1A; HUWE1; SUMO2; PSMD14; MDM2; ASB11; UCHL5; PSMD3; PSMD2; PSMD1; PSMC2; PSMC1; ADRM1; JKAMP; FBXO6; PARK2; BAG3; GADD45A; NOS2; MYC; PSMD13; PSMC4; PSMA8; UBFD1; ECD; STIP1; RANBP9; PSMD6; ZFYVE16; USP14; RUVBL1; PSM |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PSMC3 (ARP32929_T100) antibody |
| Blocking Peptide |
For anti-PSMC3 (ARP32929_T100) antibody is Catalog # AAP32929 (Previous Catalog # AAPP03953) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PSMC3 |
| Uniprot ID |
Q6IBS1 |
| Protein Name |
26S protease regulatory subunit 6A |
| Protein Accession # |
NP_002795 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_002804 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PSMC3 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
| Image 1 | Human HepG2
 | WB Suggested Anti-PSMC3 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate |
|
| Image 2 | Human kidney
 | Human kidney |
|
