| Product Number |
ARP32726_P050 |
| Product Page |
www.avivasysbio.com/notch4-antibody-middle-region-arp32726-p050.html |
| Name |
NOTCH4 Antibody - middle region (ARP32726_P050) |
| Protein Size (# AA) |
589 amino acids |
| Molecular Weight |
61kDa |
| NCBI Gene Id |
4855 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Notch 4 |
| Alias Symbols |
INT3 |
| Peptide Sequence |
Synthetic peptide located within the following region: LLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Sugaya K., et al., (1997) Gene 189:235-244 |
| Description of Target |
NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases. |
| Protein Interactions |
EGFL7; Dlg4; SMAD4; SMAD3; SMAD2; TCEB1; UBC; TP53; MDM2; MAML3; MAML2; FBXW7; MAML1; DLL4; PSEN2; NOTCH4; RBPJ; PSEN1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NOTCH4 (ARP32726_P050) antibody |
| Blocking Peptide |
For anti-NOTCH4 (ARP32726_P050) antibody is Catalog # AAP32726 (Previous Catalog # AAPP03740) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NOTCH4 |
| Uniprot ID |
Q99466-2 |
| Protein Name |
Neurogenic locus notch homolog protein 4 |
| Publications |
Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells. Stem Cells Dev. 25, 522-9 (2016). 26847503
Sun, Y. et al. Trp53 regulates Notch 4 signaling through Mdm2. J. Cell Sci. 124, 1067-76 (2011). 21402876 |
| Purification |
Affinity Purified |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NOTCH4 |
| Predicted Species Reactivity |
Human, Rat, Cow, Guinea Pig, Horse, Pig |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Pig: 100%; Rat: 93% |
| Image 1 | Human Breast
 | Immunohistochemistry with Human Breast tissue at an antibody concentration of 5.0ug/ml using anti-NOTCH4 antibody (ARP32726_P050) |
|
| Image 2 | Human Lung Tumor
 | Host: Rabbit
Target Name: NOTCH4
Sample Tissue: Human Lung Tumor
Antibody Dilution: 1.0ug/ml |
|
