MYC Antibody - N-terminal region (ARP32708_P050)

• Product Number: ARP32708_P050
• Name: MYC Antibody - N-terminal region (ARP32708_P050)
• Protein Size (# AA): 454 amino acids
• Molecular Weight: 50kDa
• NCBI Gene Id: 4609
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: V-myc myelocytomatosis viral oncogene homolog (avian)
• Alias Symbols: MRTL, MYCC, c-Myc, bHLHe39
• Peptide Sequence: Synthetic peptide located within the following region: MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Frater,J.L., (2006) Cancer Genet. Cytogenet. 166 (2), 139-145
• Description of Target: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
• Protein Interactions: UBC; USP37; USP22; KDM1A; SKP2; SMAD7; SNRNP70; CEP57; LDOC1; BRD3; KIDINS220; MAX; CSNK2B; CSNK2A1; USP28; NMI; PFDN5; TP73; EP400; SP1; PIAS2; ZBTB17; IGF2BP3; PTRF; SDK1; MRPL53; PRKCDBP; PHLDB2; KNDC1; MZT2B; RIN3; NEK11; MICALL2; NLRX1; NABP2; MYC; M
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-MYC (ARP32708_P050) antibody is Catalog # AAP32708 (Previous Catalog # AAPP03722)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MYC
• Uniprot ID: P01106
• Protein Name: Myc proto-oncogene protein
• Protein Accession #: NP_002458
• Purification: Affinity Purified
• Nucleotide Accession #: NM_002467
• Tested Species Reactivity: Human, Mouse
• Gene Symbol: MYC
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%
• Image 1: Human Muscle
  
  Human Muscle
• Image 2: Transfected 293T
  
  WB Suggested Anti-MYC Antibody Titration: 0.0625ug/ml
  Positive Control: Transfected 293T
• Image 3: Mouse Kidney
  
  Host: Mouse
  Target Name: MYC
  Sample Tissue: Mouse Kidney
  Antibody Dilution: 1ug/ml