| Product Number |
ARP32690_T100 |
| Product Page |
www.avivasysbio.com/smad6-antibody-n-terminal-region-arp32690-t100.html |
| Name |
SMAD6 Antibody - N-terminal region (ARP32690_T100) |
| Protein Size (# AA) |
496 amino acids |
| Molecular Weight |
53kDa |
| NCBI Gene Id |
4091 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
SMAD family member 6 |
| Alias Symbols |
AOVD2, MADH6, MADH7, HsT17432 |
| Peptide Sequence |
Synthetic peptide located within the following region: APRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Tsunobuchi,H., et al., (2004) Biophys. Res. Commun. 316(3),712-719 |
| Description of Target |
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. |
| Protein Interactions |
ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SMAD6 (ARP32690_T100) antibody |
| Blocking Peptide |
For anti-SMAD6 (ARP32690_T100) antibody is Catalog # AAP32690 (Previous Catalog # AAPP03704) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6 |
| Uniprot ID |
O43541 |
| Protein Name |
Mothers against decapentaplegic homolog 6 |
| Sample Type Confirmation |
There is BioGPS gene expression data showing that SMAD6 is expressed in Jurkat |
| Protein Accession # |
NP_005576 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005585 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SMAD6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 91%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-SMAD6 Antibody Titration: 0.5-1.0ug/ml
Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that SMAD6 is expressed in Jurkat |
|
| Image 2 | Human Lung
 | Human Lung |
|
| Image 3 | Human Heart
 | Human Heart |
|
